Pyroptosis and chemical classification of pyroptotic agents.

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2024-09-24 DOI:10.1007/s11030-024-10987-6

Mohammed A Hara, Mohamed Ramadan, Mohammed K Abdelhameid, Ehab S Taher, Khaled O Mohamed

引用次数: 0

Abstract

Pyroptosis, as a lytic-inflammatory type of programmed cell death, has garnered considerable attention due to its role in cancer chemotherapy and many inflammatory diseases. This review will discuss the biochemical classification of pyroptotic inducers according to their chemical structure, pyroptotic mechanism, and cancer type of these targets. A structure-activity relationship study on pyroptotic inducers is revealed based on the surveyed pyroptotic inducer chemotherapeutics. The shared features in the chemical structures of current pyroptotic inducer agents were displayed, including an essential cyclic head, a vital linker, and a hydrophilic tail that is significant for π-π interactions and hydrogen bonding. The presented structural features will open the way to design new hybridized classes or scaffolds as potent pyroptotic inducers in the future, which may represent a solution to the apoptotic-resistance dilemma along with synergistic chemotherapeutic advantage.

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火化和火化剂的化学分类。

裂解热作为一种溶解性-炎症性程序性细胞死亡，由于其在癌症化疗和许多炎症性疾病中的作用而备受关注。本综述将根据这些靶标的化学结构、裂解机制和癌症类型，讨论裂解诱导剂的生化分类。根据已调查的热诱导剂化疗药物，揭示了热诱导剂的结构-活性关系研究。研究显示了当前热诱导剂化学结构的共同特征，包括一个重要的环状头部、一个重要的连接体和一个对π-π相互作用和氢键有重要作用的亲水尾部。所展示的结构特征将为今后设计新的杂交类或支架作为强效热诱导剂开辟道路，这可能是解决凋亡耐药性难题的一种方法，同时还具有协同化疗优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;