Cell Type-Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex.

IF 3.784 3区 化学 Q1 Chemistry
Jiaqi Li, Yang Bai, Junye Ge, Yiwen Zhang, Qiuying Zhao, Dangchao Li, Baolin Guo, Shasha Gao, Yuanyuan Zhu, Guohong Cai, Xiangdong Wan, Jing Huang, Shengxi Wu
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引用次数: 0

Abstract

Despite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, the causal contributions of defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation in mice are established. Using cell type-specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. Photometry studies indicated that ACC glutamatergic neurons are activated during scratching induced by both histamine and chloroquine, whereas the activation pattern of GABAergic neurons is complicated by GABAergic subpopulations and acute itch modalities. By combining cell type- and projection-specific techniques, a thalamocortical circuit is further identified from the mediodorsal thalamus driving the itch-scratching cycle related to histaminergic and non-histaminergic itching, which is contingent on the activation of postsynaptic parvalbumin-expressing neurons in the ACC. These findings reveal a cellular and circuit signature of ACC neurons orchestrating behavioral responses to itching and may provide insights into therapies for itch-related diseases.

前扣带回皮层对急性瘙痒处理的细胞类型特异性调控
尽管人们在了解瘙痒的基本原理方面取得了重大进展,但对其皮层机制的了解仍然很少。在本文中,研究人员确定了前扣带回皮层(ACC)神经元群对小鼠急性瘙痒调节的因果关系。通过细胞类型特异性操作,证明了扣带皮层谷氨酸能神经元和 GABA 能神经元在调节急性瘙痒中的相反功能。光度测量研究表明,在组胺和氯喹诱导的搔痒过程中,ACC谷氨酸能神经元会被激活,而GABA能神经元的激活模式则因GABA能亚群和急性瘙痒模式而复杂。通过结合细胞类型和投射特异性技术,进一步确定了丘脑内侧的丘脑皮层回路,该回路驱动与组胺能和非组胺能瘙痒相关的痒-抓循环,而痒-抓循环取决于突触后副发光素表达神经元在ACC的激活。这些发现揭示了协调瘙痒行为反应的ACC神经元的细胞和电路特征,并可能为瘙痒相关疾病的疗法提供启示。
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来源期刊
ACS Combinatorial Science
ACS Combinatorial Science CHEMISTRY, APPLIED-CHEMISTRY, MEDICINAL
自引率
0.00%
发文量
0
审稿时长
1 months
期刊介绍: The Journal of Combinatorial Chemistry has been relaunched as ACS Combinatorial Science under the leadership of new Editor-in-Chief M.G. Finn of The Scripps Research Institute. The journal features an expanded scope and will build upon the legacy of the Journal of Combinatorial Chemistry, a highly cited leader in the field.
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