Cardiorespiratory fitness, independent of APOE genotype, is associated with better neurocognitive function in older adults: An ERP study

IF 3.1 2区心理学 Q2 HOSPITALITY, LEISURE, SPORT & TOURISM

Psychology of Sport and Exercise Pub Date : 2024-09-21 DOI:10.1016/j.psychsport.2024.102748

Yu-Kai Chang , Jennifer L. Etnier , Ruei-Hong Li , Ying-Chu Chen , Chen-Sin Hung , Feng-Tzu Chen , Chung-Yu Chen , Chien-Heng Chu

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引用次数: 0

Abstract

This study assessed the association between cardiorespiratory fitness and carriage of the apolipoprotein-E ε4 (APOE ε4) alleles and cognitive function using behavioral and neuroelectric measures obtained from cognitively normal older adults. A total of 159 adults aged 50–70 years were categorized into four groups based on cardiorespiratory fitness (i.e., higher vs. lower fitness) and the APOE genotype status (i.e., APOE ε4 carrier vs. non-carrier). Neurocognitive functions were indexed using response time and accuracy measures from the Stroop task and averaged mean P3 amplitudes of event-related potentials obtained during task performance. A significant main effect of cardiorespiratory fitness (p = .01) and the Stroop congruency (p < .001), but not the APOE genotype status, with shorter response times for the higher fitness group than for the lower fitness group and for the congruent condition relative to the incongruent condition, were observed. Similar findings were also revealed, with larger averaged mean P3 amplitudes for the higher fitness group than those in the lower fitness group, and in the congruent condition than in the incongruent condition. These findings suggest that higher cardiorespiratory fitness is linked to better neurocognitive function, and the positive association is evident regardless of the APOE ε4 status and the cognitive domain assessed in cognitively normal older adults.

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独立于 APOE 基因型的心肺功能与老年人更好的神经认知功能相关：ERP研究

本研究通过对认知正常的老年人进行行为和神经电测量，评估了心肺功能、携带载脂蛋白-E ε4等位基因（APOE ε4）与认知功能之间的关系。根据心肺功能（即较高与较低）和 APOE 基因型（即 APOE ε4 携带者与非携带者）将 159 名 50-70 岁的成年人分为四组。神经认知功能的指标包括Stroop测试的反应时间和准确性，以及任务执行过程中获得的事件相关电位P3振幅的平均值。观察发现，心肺功能（p = .02）和 Stroop 一致性（p < .001）有明显的主效应，但 APOE 基因型状态没有明显的主效应。类似的结果还显示，体能较高组的平均 P3 振幅大于体能较低组的平均 P3 振幅，且在一致条件下大于不一致条件下。这些研究结果表明，较高的心肺功能与较好的神经认知功能有关，而且无论 APOE ε4 状态如何，在认知正常的老年人中评估的认知领域如何，这种正相关都是显而易见的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychology of Sport and Exercise 医学-心理学

CiteScore

6.40

自引率

5.90%

发文量

172

审稿时长

69 days

期刊介绍： Psychology of Sport and Exercise is an international forum for scholarly reports in the psychology of sport and exercise, broadly defined. The journal is open to the use of diverse methodological approaches. Manuscripts that will be considered for publication will present results from high quality empirical research, systematic reviews, meta-analyses, commentaries concerning already published PSE papers or topics of general interest for PSE readers, protocol papers for trials, and reports of professional practice (which will need to demonstrate academic rigour and go beyond mere description). The CONSORT guidelines consort-statement need to be followed for protocol papers for trials; authors should present a flow diagramme and attach with their cover letter the CONSORT checklist. For meta-analysis, the PRISMA prisma-statement guidelines should be followed; authors should present a flow diagramme and attach with their cover letter the PRISMA checklist. For systematic reviews it is recommended that the PRISMA guidelines are followed, although it is not compulsory. Authors interested in submitting replications of published studies need to contact the Editors-in-Chief before they start their replication. We are not interested in manuscripts that aim to test the psychometric properties of an existing scale from English to another language, unless new validation methods are used which address previously unanswered research questions.