Landscape of stroke comorbidities: A disease-wide association study

IF 5.6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Ming Zheng , Carl J. Lavie
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引用次数: 0

Abstract

Stroke is a leading cause of death and disability worldwide, with diverse comorbidities that influence its clinical outcomes. However, a comprehensive understanding of the short- and long-term patterns of stroke-related comorbidities remains limited. To address this gap, we conducted a disease-wide association study (DWAS) to systematically explore the landscape of stroke comorbidities in a population-based cohort. Using data from the FinnGen cohort, which included 337,194 participants and 27,496 ischemic stroke cases, we analyzed 1,757 medical events as potential stroke comorbidities. We employed Cox proportional hazards regression, adjusting for sex and age, to identify significant associations between stroke and these medical events. Comorbidities were classified into pre- and post-stroke categories, and their temporal patterns were analyzed over a 1- to 15-year follow-up period. Our findings revealed that stroke comorbidities span multiple disease taxonomies, with significant enrichment in the circulatory, digestive, and musculoskeletal systems. Notably, the study identified distinct pre-stroke and post-stroke comorbidities that persist or evolve over time, supporting the concept of a disease continuum. These temporal patterns suggest that stroke risk and outcomes are shaped by sequential comorbidities rather than simultaneous occurrences. This study provides the most comprehensive profile of stroke comorbidities to date, highlighting the interconnected nature of diseases. By mapping the progression of comorbidities across time and disease categories, DWAS offers valuable insights for early intervention and long-term treatment. Our findings emphasize the importance of viewing stroke as part of a broader disease continuum, offering new opportunities for prevention, diagnosis, and treatment strategies tailored to individual risk profiles.
中风并发症情况。
脑卒中是导致全球死亡和残疾的主要原因,其多种并发症影响着临床预后。然而,对卒中相关合并症的短期和长期模式的全面了解仍然有限。为了填补这一空白,我们开展了一项全疾病关联研究(DWAS),以系统地探索人群队列中中风合并症的分布情况。芬兰基因队列包括 337,194 名参与者和 27,496 例缺血性中风病例,我们利用该队列的数据分析了作为潜在中风合并症的 1,757 个医疗事件。我们采用 Cox 比例危险度回归,并对性别和年龄进行了调整,以确定中风与这些医疗事件之间的显著关联。合并症分为卒中前和卒中后两类,并对其在 1-15 年随访期内的时间模式进行了分析。我们的研究结果表明,中风合并症涉及多种疾病分类,其中循环系统、消化系统和肌肉骨骼系统的合并症明显增多。值得注意的是,该研究发现了卒中前和卒中后不同的合并症,这些合并症随着时间的推移而持续或演变,支持了疾病连续体的概念。这些时间模式表明,中风风险和预后是由相继发生的合并症而不是同时发生的合并症决定的。这项研究提供了迄今为止最全面的中风合并症概况,突出了疾病的相互关联性。通过描绘合并症在不同时间和不同疾病类别中的进展,DWAS 为早期干预和长期治疗提供了宝贵的见解。我们的研究结果强调了将中风视为更广泛的疾病连续体的一部分的重要性,为针对个体风险特征的预防、诊断和治疗策略提供了新的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in cardiovascular diseases
Progress in cardiovascular diseases 医学-心血管系统
CiteScore
10.90
自引率
6.60%
发文量
98
审稿时长
7 days
期刊介绍: Progress in Cardiovascular Diseases provides comprehensive coverage of a single topic related to heart and circulatory disorders in each issue. Some issues include special articles, definitive reviews that capture the state of the art in the management of particular clinical problems in cardiology.
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