Progesterone receptor B over progesterone receptor A prevents recurrence in bilateral endometriomas.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI:10.1590/1806-9282.20240485
Ozgur Aslan, Sukru Yildiz, Cihan Kaya, Serdar Altinay, Ilke Esin Aydiner, Esra Karabulut, Murat Ekin, Levent Yasar
{"title":"Progesterone receptor B over progesterone receptor A prevents recurrence in bilateral endometriomas.","authors":"Ozgur Aslan, Sukru Yildiz, Cihan Kaya, Serdar Altinay, Ilke Esin Aydiner, Esra Karabulut, Murat Ekin, Levent Yasar","doi":"10.1590/1806-9282.20240485","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Endometriosis is a disease in which stromal cells and endometrial glands extend outside of the uterine cavity. Nevertheless, treatment failure and recurrence cause difficulties in management. This study aimed to evaluate the receptor-level components of bilateral endometriomas in the recurrence state.</p><p><strong>Methods: </strong>Our retrospective cohort study was conducted with patients who underwent surgery for bilateral endometriomas between 2015 and 2021. In total, 113 patients were allocated. A total of 76 patients did not meet the eligibility criteria, and the data of 37 patients were evaluated. Medical treatments, recurrences, and postoperative follow-up data were collected. In archived tissue samples, measurements of progesterone receptor A and progesterone receptor B, histoscores and immunoreactivity scores, and their ratios were calculated in the group that received no postoperative medical treatment. Criteria for recurrence were a repeat operation and/or the detection of a new endometrioma>2 cm at the follow-up examination.</p><p><strong>Results: </strong>No recurrence was observed in 73.0% (n=27) of the cases, whereas recurrence was observed in 27.0% (n=10) of the participants. Patients without recurrence had significantly higher progesterone receptor B histoscore/progesterone receptor A histoscore and progesterone receptor B immunoreactivity score/progesterone receptor A immunoreactivity score results (p=0.01). Nevertheless, when the histoscores and immunoreactivity scores for both receptors were contrasted separately, there was no appreciable difference between them.</p><p><strong>Conclusion: </strong>The dominance of progesterone receptor B over progesterone receptor A was inversely proportional to the recurrence status in bilateral endometriomas. Furthermore, our study revealed that assessing receptor levels alone did not result in a significant difference in recurrence.</p>","PeriodicalId":94194,"journal":{"name":"Revista da Associacao Medica Brasileira (1992)","volume":"70 9","pages":"e20240485"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415056/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Associacao Medica Brasileira (1992)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1806-9282.20240485","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Endometriosis is a disease in which stromal cells and endometrial glands extend outside of the uterine cavity. Nevertheless, treatment failure and recurrence cause difficulties in management. This study aimed to evaluate the receptor-level components of bilateral endometriomas in the recurrence state.

Methods: Our retrospective cohort study was conducted with patients who underwent surgery for bilateral endometriomas between 2015 and 2021. In total, 113 patients were allocated. A total of 76 patients did not meet the eligibility criteria, and the data of 37 patients were evaluated. Medical treatments, recurrences, and postoperative follow-up data were collected. In archived tissue samples, measurements of progesterone receptor A and progesterone receptor B, histoscores and immunoreactivity scores, and their ratios were calculated in the group that received no postoperative medical treatment. Criteria for recurrence were a repeat operation and/or the detection of a new endometrioma>2 cm at the follow-up examination.

Results: No recurrence was observed in 73.0% (n=27) of the cases, whereas recurrence was observed in 27.0% (n=10) of the participants. Patients without recurrence had significantly higher progesterone receptor B histoscore/progesterone receptor A histoscore and progesterone receptor B immunoreactivity score/progesterone receptor A immunoreactivity score results (p=0.01). Nevertheless, when the histoscores and immunoreactivity scores for both receptors were contrasted separately, there was no appreciable difference between them.

Conclusion: The dominance of progesterone receptor B over progesterone receptor A was inversely proportional to the recurrence status in bilateral endometriomas. Furthermore, our study revealed that assessing receptor levels alone did not result in a significant difference in recurrence.

孕酮受体 B 比孕酮受体 A 更能预防双侧子宫内膜异位症的复发。
目的:子宫内膜异位症是一种基质细胞和子宫内膜腺体延伸到子宫腔外的疾病。然而,治疗失败和复发给治疗带来了困难。本研究旨在评估复发状态下双侧子宫内膜异位症的受体水平成分:我们对 2015 年至 2021 年期间接受双侧子宫内膜异位症手术的患者进行了回顾性队列研究。共有 113 名患者被分配。共有 76 例患者不符合资格标准,对 37 例患者的数据进行了评估。收集了医疗、复发和术后随访数据。在存档组织样本中,计算了未接受术后药物治疗组的孕酮受体A和孕酮受体B、组织评分和免疫反应评分及其比率。复发的标准是再次手术和/或在随访检查中发现新的子宫内膜异位症>2 厘米:73.0%的病例(n=27)未观察到复发,而27.0%的参与者(n=10)观察到复发。未复发患者的孕酮受体B组织评分/孕酮受体A组织评分和孕酮受体B免疫反应评分/孕酮受体A免疫反应评分结果均明显高于复发患者(P=0.01)。然而,如果将两种受体的组织评分和免疫反应评分分别进行对比,它们之间并无明显差异:结论:在双侧子宫内膜异位症中,孕酮受体B的优势与孕酮受体A的复发状况成反比。此外,我们的研究还发现,单独评估受体水平并不会导致复发率的显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信