How Do People Who Undergo Ketamine Treatment for a Psychiatric Problem Subjectively Experience This Intervention? A Meta-Synthesis of Qualitative Studies.

Melanie Trimmel, Antonia Renner, Alexander Kaltenboeck
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Abstract

Ketamine treatment has shown promising effects for different mental disorders. Yet, little is known on how people who receive ketamine for a psychiatric problem subjectively experience undergoing this intervention. We conducted a systematic literature search to identify relevant qualitative research on the first-person experience of undergoing ketamine treatment in a psychiatric context. 24 eligible studies were identified and analysed using a thematic meta-synthesis approach. Three main themes were identified. First, 'The Ketamine treatment experience can be understood as a three-stage journey with unique clinical features at each stage'. Second, 'The subjective experience of acute ketamine treatment is multifaceted and complex'. Third, 'Ketamine treatment can have different positive effects-but what happens if it does not work?'. In summary, the subjective experience of receiving ketamine treatment for a psychiatric problem can be understood as a journey whereby patients move towards, then undergo, and eventually depart from ketamine. Before treatment, the experiential focus lies on expectations, hopes, and feelings towards the drug. During treatment, the drug's multifaceted psychotropic effects and how they are emotionally appraised become central to experience. Once treatment is finished, the focus is on the presence or absence of clinically relevant effects. The conceptual framework we propose can guide further qualitative research on this topic and aid mental health professionals to better understand the experience of patients who undergo ketamine treatment for a psychiatric problem.

因精神问题接受氯胺酮治疗的人如何主观体验这种干预?定性研究的元综合。
氯胺酮治疗对不同的精神疾病有良好的疗效。然而,人们对接受氯胺酮治疗的精神疾病患者在接受这种干预时的主观感受却知之甚少。我们进行了一次系统性文献检索,以确定在精神病治疗中接受氯胺酮治疗的第一人称体验的相关定性研究。我们确定了 24 项符合条件的研究,并采用主题元综合法对其进行了分析。研究确定了三大主题。第一,"氯胺酮治疗经历可以理解为一个三阶段的旅程,每个阶段都有其独特的临床特征"。第二,"氯胺酮急性治疗的主观体验是多方面和复杂的"。第三,"氯胺酮治疗可以产生不同的积极效果--但如果无效会怎样?总之,因精神问题而接受氯胺酮治疗的主观体验可以理解为患者走向氯胺酮、接受氯胺酮治疗并最终离开氯胺酮的一个过程。治疗前,体验的重点在于对药物的期望、希望和感受。在治疗过程中,药物的多方面精神作用以及如何对这些作用进行情感评价成为体验的核心。治疗结束后,重点则是临床相关效果的存在与否。我们提出的概念框架可以指导有关这一主题的进一步定性研究,并帮助精神卫生专业人员更好地理解因精神问题而接受氯胺酮治疗的患者的体验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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