Platelet transfusion.

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI:10.1097/MOH.0000000000000843
Allison Mo, Erica Wood, Zoe McQuilten
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引用次数: 0

Abstract

Purpose of review: Platelet transfusions, used as prophylaxis or treatment for bleeding, are potentially life-saving. In many countries, demand for platelet transfusion is rising. Platelets are a limited and costly resource, and it is vital that they are used appropriately. This study will explore the evidence behind platelet transfusions in different contexts, in particular recent and important research in this area.

Recent findings: Recent randomized clinical trials demonstrate the efficacy of platelet transfusions in some contexts but potential detrimental effects in others. Platelet transfusions also carry risk of transfusion reactions, bacterial contamination and platelet transfusion refractoriness. Observational and clinical studies, which highlight approaches to mitigate these risks, will be discussed. There is growing interest in cold-stored or cryopreserved platelet units, which may improve platelet function and availability. Clinical trials also highlight the efficacy of other supportive measures such as tranexamic acid or thrombopoietin receptor agonists in patients with bleeding.

Summary: Although platelet transfusions are beneficial in many patients, there remain many settings in which the optimal use of platelet transfusions is unclear, and some situations in which they may have detrimental effects. Future clinical trials are needed to determine optimal use of platelet transfusions in different patient populations.

血小板输注。
审查目的:输注血小板可用于预防或治疗出血,有可能挽救生命。在许多国家,输注血小板的需求正在上升。血小板是一种有限而昂贵的资源,合理使用至关重要。本研究将探讨在不同情况下输注血小板背后的证据,特别是该领域近期的重要研究:最近的随机临床试验表明,输注血小板在某些情况下是有效的,但在另一些情况下可能会产生不利影响。血小板输注还存在输血反应、细菌污染和血小板输注耐受性等风险。观察性研究和临床研究强调了降低这些风险的方法,将对这些研究进行讨论。人们对冷藏或低温保存的血小板单位越来越感兴趣,这可能会改善血小板的功能和可用性。临床试验还强调了其他支持性措施(如氨甲环酸或血小板生成素受体激动剂)对出血患者的疗效。摘要:尽管输注血小板对许多患者有益,但仍有许多情况下血小板输注的最佳使用方法尚不明确,有些情况下输注血小板可能会产生不利影响。未来需要进行临床试验,以确定在不同患者群体中输注血小板的最佳使用方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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