Update on Palmar Fasciitis and Polyarthritis Syndrome: A Systematic Review.

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2024-09-18 DOI:10.1016/j.jbspin.2024.105776

Xiao Ma, Xing-Yu Li, Jing-Wen Wang, Dong-Lai Ma

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引用次数: 0

Abstract

Objectives: This systematic review aims to (1) summarize the clinical, laboratory, and imaging characteristics of Palmar Fasciitis and Polyarthritis Syndrome (PFPAS) patients and (2) evaluate the effectiveness of different treatments.

Methods: We conducted a systematic search of three electronic databases (Scopus, Embase, and PubMed) from inception to December 31, 2023. We presented demographic and clinical features, along with laboratory factors and imaging examinations of PFPAS patients. Additionally, we outline main treatments and evaluate therapeutic effectiveness.

Results: A total of 121 patients were included in the analysis, with a mean onset age of 61.4 years. Swelling or thickening (49.6%, n=60/121) and pain (41.3%, n=50/121) were characteristic musculoskeletal symptoms of the hands. The median time between onset of PFPAS symptoms and detection of malignancy was 4 months, with a median survival of 13.0 months (range = 2 to 69). The abnormal rate of ultrasound, magnetic resonance imaging, and bone scan of the musculoskeletal system was more than 80%. Effective therapeutic responses were observed in 66.0% (n=33/50) of cases treated with chemotherapies and 79.2% (n=19/24) with operations. Two patients who received biologics achieved partial remission.

Conclusion: PFPAS is a rare paraneoplastic condition, and early recognition of its distinctive symptoms may lead to the detection of underlying malignancy and timely treatments, potentially saving lives.

查看原文本刊更多论文

掌筋膜炎和多关节炎综合征的最新进展：系统回顾

目的：本系统性综述旨在：（1）总结掌筋膜炎和多关节炎综合征（PFPAS）患者的临床、实验室和影像学特征；（2）评估不同治疗方法的有效性：我们对三个电子数据库（Scopus、Embase 和 PubMed）进行了系统检索，检索时间从开始到 2023 年 12 月 31 日。我们介绍了 PFPAS 患者的人口统计学特征、临床特征、实验室因素和影像学检查。此外，我们还概述了主要治疗方法并评估了疗效：共有 121 名患者纳入分析，平均发病年龄为 61.4 岁。肿胀或增厚（49.6%，n=60/121）和疼痛（41.3%，n=50/121）是手部肌肉骨骼的特征性症状。从出现 PFPAS 症状到发现恶性肿瘤的中位时间为 4 个月，中位生存期为 13.0 个月（范围 = 2 至 69 个月）。肌肉骨骼系统超声波、磁共振成像和骨扫描的异常率超过80%。66.0%（33/50）的化疗病例和79.2%（19/24）的手术治疗病例观察到了有效的治疗反应。两名接受生物制剂治疗的患者获得了部分缓解：PFPAS是一种罕见的副肿瘤性疾病，早期识别其独特的症状可能会发现潜在的恶性肿瘤并及时治疗，从而挽救生命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.