{"title":"[Clinical Implementation of Amyloid PET: Latest Findings and Practical Approaches in the Diagnosis and Treatment of Alzheimer's Disease].","authors":"Atsushi Michael Kimura, Hitoshi Shimada","doi":"10.11477/mf.1416202727","DOIUrl":null,"url":null,"abstract":"<p><p>Amyloid PET plays a crucial role in the early diagnosis of Alzheimer's disease and the determination of the feasibility of disease-modifying therapies. It offers several advantages, including high sensitivity and specificity, minimal invasiveness, and the ability to provide spatial evaluation, all of which contribute to the optimization of dementia care. However, proper use and interpretation of the results require a thorough understanding of their limitations. Although careful consideration is necessary when using scans on asymptomatic individuals, clinical applications could broaden if preemptive treatments and high-precision individual risk assessments for the preclinical stage are developed.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 9","pages":"1019-1027"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Nerve","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11477/mf.1416202727","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Amyloid PET plays a crucial role in the early diagnosis of Alzheimer's disease and the determination of the feasibility of disease-modifying therapies. It offers several advantages, including high sensitivity and specificity, minimal invasiveness, and the ability to provide spatial evaluation, all of which contribute to the optimization of dementia care. However, proper use and interpretation of the results require a thorough understanding of their limitations. Although careful consideration is necessary when using scans on asymptomatic individuals, clinical applications could broaden if preemptive treatments and high-precision individual risk assessments for the preclinical stage are developed.
淀粉样蛋白 PET 在阿尔茨海默病的早期诊断和确定改变病情疗法的可行性方面发挥着至关重要的作用。它具有多种优势,包括灵敏度和特异性高、微创性和提供空间评估的能力,所有这些都有助于优化痴呆症护理。然而,要正确使用和解释扫描结果,就必须充分了解其局限性。虽然在对无症状的人使用扫描时需要慎重考虑,但如果能开发出临床前阶段的先期治疗和高精度个体风险评估,就能扩大临床应用。