Differences and Similarities Between Primary Open Angle Glaucoma and Primary Angle-Closure Glaucoma.

IF 3.1 Q1 OPHTHALMOLOGY
Eye and Brain Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI:10.2147/EB.S472920
Yiwei Wang, Yanzhi Guo, Yang Zhang, Shouyue Huang, Yisheng Zhong
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引用次数: 0

Abstract

Glaucoma is the leading cause of irreversible blindness worldwide. It is an ocular disease characterized by an increase in intraocular pressure or, in some cases, normal intraocular pressure, which leads to optic nerve damage and progressive constriction of the visual field (VF). Primary Open-Angle Glaucoma (POAG) and Primary Angle-Closure Glaucoma (PACG) represent the predominant forms of glaucoma. Numerous hypotheses have been posited to elucidate the pathogenic mechanisms underlying these conditions. There is an emerging understanding of the distinct pathological processes that differentiate the various types of glaucoma. While some similarities in the mechanisms between PACG and POAG have been suggested, evidence indicates that there are also significant differences between the two. This review synthesizes the similarities and differences in the etiology of optic neuropathy caused by POAG and PACG, considering their respective pathophysiological mechanisms, the morphology of the optic disc and surrounding tissues, genetic characteristics, optical coherence tomography angiography, optical coherence tomography, and structural and functional features from VF examinations. These characteristics may contribute to a deeper comprehension of the underlying pathogenesis of glaucoma and enhance the management of different types of this ocular condition.

原发性开角型青光眼与原发性闭角型青光眼的异同。
青光眼是导致全球不可逆失明的主要原因。青光眼是一种眼部疾病,其特征是眼压升高,或在某些情况下眼压正常,从而导致视神经损伤和视野逐渐缩小(VF)。原发性开角型青光眼(POAG)和原发性闭角型青光眼(PACG)是青光眼的主要类型。为了阐明这些病症的致病机制,人们提出了许多假设。人们对区分各种类型青光眼的不同病理过程有了新的认识。虽然 PACG 和 POAG 的发病机制有一些相似之处,但有证据表明两者之间也存在显著差异。本综述综合考虑了 POAG 和 PACG 各自的病理生理机制、视盘和周围组织的形态、遗传特征、光学相干断层血管造影术、光学相干断层扫描以及 VF 检查的结构和功能特征,总结了这两种类型青光眼引起的视神经病变在病因学上的异同。这些特征有助于加深对青光眼潜在发病机制的理解,并加强对不同类型青光眼的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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