Using harmonized FITBIR datasets to examine associations between TBI history and cognitive functioning.

IF 1.4 4区 心理学 Q4 CLINICAL NEUROLOGY
Maya E O'Neil, David Cameron, Danielle Krushnic, William Baker Robinson, Sara Hannon, Kate Clauss, Tamara Cheney, Lawrence Cook, Meike Niederhausen, Mary Jo Pugh
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Abstract

Objective: Demonstrate how patient-level traumatic brain injury (TBI) data from studies in the Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System can be harmonized and pooled to examine relationships between TBI and cognitive functioning.

Method: We harmonized and pooled data across studies and analyzed rates of probable cognitive functioning deficits by TBI history and severity.

Results: Four publicly available FITBIR studies with 3,445 participants included data on cognitive dysfunction, though only one included comparison groups (mild TBI vs. no history of TBI) and could be used in the final comparative analyses. Of the 1,539 participants, 82% had a history of mild TBI and 67% had data suggesting the presence of cognitive dysfunction. Participants with a history of mild TBI were mostly male (87%), 25-39 years old (53%), and Non-Hispanic White (60%). Conclusions: One publicly available FITBIR study reported cognitive dysfunction data as of January 2021, though findings were similar to prior research and supported an association between mild TBI and cognitive dysfunction. This proof-of-concept study shared newly developed methods including harmonization, analysis syntax, and meta-data via the FITBIR website to encourage dissemination of these TBI data resources in line with FAIR data goals.

利用统一的 FITBIR 数据集研究创伤性脑损伤病史与认知功能之间的关联。
目标:展示如何协调和汇集联邦机构间创伤性脑损伤研究(FITBIR)信息系统中各项研究的患者级别创伤性脑损伤(TBI)数据,以研究TBI与认知功能之间的关系:我们协调并汇总了各项研究的数据,并根据创伤性脑损伤病史和严重程度分析了可能的认知功能障碍率:四项公开的 FITBIR 研究共有 3,445 名参与者,其中包括认知功能障碍的数据,但只有一项研究包括对比组(轻度 TBI 与无 TBI 史),可用于最终的对比分析。在 1539 名参与者中,82% 有轻度 TBI 病史,67% 有数据表明存在认知功能障碍。有轻度创伤性脑损伤病史的参与者多为男性(87%)、25-39 岁(53%)和非西班牙裔白人(60%)。结论:一项公开的 FITBIR 研究报告了截至 2021 年 1 月的认知功能障碍数据,尽管研究结果与之前的研究相似,并支持轻度 TBI 与认知功能障碍之间存在关联。这项概念验证研究通过 FITBIR 网站分享了新开发的方法,包括协调、分析语法和元数据,以鼓励按照 FAIR 数据目标传播这些 TBI 数据资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
CiteScore
4.50
自引率
11.80%
发文量
134
期刊介绍: pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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