Preventable vision loss in children with Coats disease

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.104000

Francisco Altamirano MD, Efren Gonzalez MD, Ankoor S. Shah MD, PhD, Isdin Oke MD, MPH

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引用次数: 0

Abstract

Purpose

To describe the prevalence and risk factors associated with amblyogenic refractive error in children with Coats disease.

Methods

The medical records of children (<18 years of age) with unilateral Coats disease treated at a single tertiary care center were retrospectively reviewed. Data collected included patient demographics, ocular examinations, and treatments. Outcomes included the prevalence and factors associated with amblyogenic refractive error.

Results

A total of 50 children (82% male) were included; of these, 37 (74%) had refractive data to review. The median age at presentation was 5 years (IQR, 2-10). The Coats disease classification was stage 1 in 1 (2%), stage 2 in 29 (58%), and stage 3 or greater in 20 (40%). Most children (76%) had at least one visit with a pediatric specialist; the rest were only seen by a retina specialist. Among patients with refractive data, amblyogenic refractive error was identified in 46%. Glasses were prescribed to 50% of children. Children diagnosed at an earlier age had increased odds of amblyogenic refractive error (OR = 0.72; 95% CI, 0.57-0.91; P = 0.006) than those diagnosed at an older age.

Conclusions

Our results suggest that amblyogenic refractive error is prevalent among children with Coats disease, and refractions are not always performed. There is a need to coordinate care between pediatric and retina specialists caring for children with Coats disease to ensure timely diagnosis of amblyogenic refractive error to optimize visual outcomes in this population.

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柯茨病儿童可预防的视力丧失。

目的：描述科茨病儿童弱视性屈光不正的患病率和相关风险因素：结果：共纳入 50 名儿童（82% 为男性）的病历：共纳入 50 名儿童（82% 为男性），其中 37 名儿童（74%）有屈光数据可供审查。发病时的中位年龄为 5 岁（IQR，2-10 岁）。1 名儿童（2%）的科茨氏病为 1 期，29 名儿童（58%）为 2 期，20 名儿童（40%）为 3 期或以上。大多数患儿（76%）至少接受过一次儿科专家的诊治，其余患儿只接受过视网膜专家的诊治。在有屈光数据的患者中，46%的患者被确认为弱视性屈光不正。50%的儿童配戴了眼镜。与年龄较大的儿童相比，年龄较小的儿童被诊断出弱视性屈光不正的几率更高（OR = 0.72；95% CI，0.57-0.91；P = 0.006）：我们的研究结果表明，弱视性屈光不正在科茨病患儿中很普遍，而屈光检查并不总是进行。有必要协调儿科专家和视网膜专家对高兹病患儿的治疗，以确保及时诊断弱视性屈光不正，从而优化该人群的视觉预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.