Intravenous fluorescein overdose in a child undergoing fluorescein angiography

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.103996

Rhea W. Teng BS, Michael T.B. Nguyen MD, David G. Hunter MD, PhD, Pablo Altschwager MD

引用次数: 0

Abstract

Fluorescein angiography is a fluorescent dye-based imaging procedure, most commonly indicated in the pediatric setting to evaluate peripheral retinal vascular lesions. Fluorescein dye is organic, water soluble, and largely excreted renally, with a reassuring safety profile at therapeutic doses. While toxicity with intrathecal overdose has been reported, the effect of intravenous exposure to supratherapeutic levels has not been previously documented in the literature. We report the case of a 10-month-old girl with incontinentia pigmenti who received more than four times the recommended dosage of fluorescein during scheduled fluorescein angiography and developed marked yellowing of skin, sclera, stool, and urine. She was seen by the toxicology team and underwent monitoring for 8 hours before being discharged, with no adverse consequences detected during follow-up.

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一名接受荧光素血管造影术的儿童静脉注射荧光素过量。

荧光素血管造影是一种基于荧光染料的成像程序，最常用于儿科，以评估外周视网膜血管病变。荧光素染料是有机物，可溶于水，大部分经肾脏排泄，治疗剂量下的安全性令人放心。虽然已有鞘内过量中毒的报道，但静脉注射超治疗剂量的影响尚未见文献记载。我们报告了一例 10 个月大的猪尿失禁女孩的病例，她在预定的荧光素血管造影检查中接受了超过推荐剂量四倍的荧光素，并出现皮肤、巩膜、粪便和尿液明显变黄。毒理学小组对她进行了诊治，并在出院前对她进行了 8 小时的监护，随访期间未发现任何不良后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.