Incidence and presenting clinical features of pediatric keratoconus in a US population

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.104003

Marybeth K. Farazdaghi MD , Erick D. Bothun MD , Meagan Tran , David O. Hodge MS , Brian G. Mohney MD

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Abstract

Purpose

To report both the incidence of pediatric keratoconus (PKC) in a population-based cohort and the risk for undergoing corneal surgery over a 20-year period at a single institution.

Methods

The medical records of all patients <19 years of age diagnosed with keratoconus while residing in Olmsted County, Minnesota, from January 1, 1975, through December 31, 2019, were retrospectively reviewed. The records of patients <19 years with keratoconus examined at our institution from January 1, 2001, through December 31, 2020, were also reviewed.

Results

The incidence of PKC in this population over the 45-year study period was 2.48 cases per 100,000 people per year (95% CI, 1.67-3.29). The mean age at diagnosis was 15.25 years (range, 7-18) years, and 28 (77.8%) were male. During a mean follow-up of 2.8 years (range, 0-17.3 years), 33 of 71 patients managed at our institution (46%) underwent at least one corneal procedure. In this cohort, the Kaplan-Meier risk of requiring a procedure by 10 years following diagnosis was 60%.

Conclusions

The incidence of PKC in Olmsted County, Minnesota, over a 45-year period was 2.48 cases per 100,000 people per year. Nearly half of the patients managed at our institution over the past 20 years required a procedure during follow-up.

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美国儿童角膜病的发病率和临床表现特征。

目的：报告一个以人群为基础的队列中小儿角膜病（PKC）的发病率以及在一家机构的 20 年间接受角膜手术的风险：方法：所有患者的病历：在45年的研究期间，该人群中PKC的发病率为每年每10万人中有2.48例（95% CI，1.67-3.29）。确诊时的平均年龄为 15.25 岁（7-18 岁不等），28 人（77.8%）为男性。在平均 2.8 年（0-17.3 年）的随访期间，我院收治的 71 名患者中有 33 人（46%）至少接受了一次角膜手术。在这组患者中，确诊后 10 年内需要接受角膜手术的 Kaplan-Meier 风险为 60%：明尼苏达州奥姆斯特德县在45年间的PKC发病率为每年每10万人中2.48例。过去20年中，在本院接受治疗的患者中有近一半在随访期间需要接受手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.