Fluoxetine as a possible treatment for adult amblyopia: results of a double-blind, randomized, placebo-controlled trial

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.104009

Arash Mirmohammadsadeghi MD , Alireza Mousavi MD , Mohammad Reza Akbari MD , Hassan Khojasteh MD , Babak Masoomian MD , Motahhareh Sadeghi MD , Samira Yadegari MD , Hassan Asadigandomani MD

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Abstract

Purpose

To evaluate the effects of oral fluoxetine on visual acuity and visual-evoked potential (VEP) parameters in adults patching for amblyopia.

Methods

In this randomized clinical trial, adults (>18 years of age) with anisometropic or strabismic amblyopia were assigned randomly to a treatment (fluoxetine) group or a placebo group. Standard treatments for amblyopia (glasses prescription and patching) were prescribed for 4 months for all patients beforehand. The first group received fluoxetine (20 mg per day) and the second group received a placebo for 3 months, both continuing patching. Visual acuity evaluation and VEP were performed before and after treatment.

Results

A total of 55 participants were included: 29 in the fluoxetine group and 26 in the placebo group. Mean age was 27.2 ± 8.6 years (18-54). The mean logMAR visual acuity of the amblyopic eye improved by 0.20 ± 0.24 (0-0.8) in the fluoxetine group (P < 0.001) and by 0.08 ± 0.15 (0-0.7) in the placebo group (P = 0.01); mean logMAR improvement was significantly higher in the fluoxetine group than in the placebo group (P = 0.04). At the end of the study, mean visual acuity of the fluoxetine group (0.36 ± 0.21 log MAR) was better than the placebo group (0.43 ± 0.35 log MAR). Among the VEP parameters, N75 amplitude did not change significantly in either group relative to baseline, but the changes were statistically significantly different between the two groups (P = 0.05); N135 latency improved from baseline in the fluoxetine group (P = 0.03).

Conclusions

In our study cohort, fluoxetine treatment resulted in greater improvement in visual acuity than placebo during patching for adult amblyopia.

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氟西汀作为治疗成人弱视的一种可能方法：一项双盲、随机、安慰剂对照试验的结果。

目的：评估口服氟西汀对成人弱视患者视力和视觉诱发电位（VEP）参数的影响：在这项随机临床试验中，患有各向异性弱视或斜视的成年人（18 岁以上）被随机分配到治疗组（氟西汀）或安慰剂组。所有患者均接受为期 4 个月的弱视标准治疗（配眼镜和戴眼罩）。第一组接受氟西汀治疗（每天 20 毫克），第二组接受安慰剂治疗 3 个月。治疗前后均进行了视力评估和 VEP：结果：共纳入 55 名参与者：结果：共纳入 55 名参与者：氟西汀组 29 人，安慰剂组 26 人。平均年龄为 27.2 ± 8.6 岁（18-54 岁）。氟西汀组弱视眼的平均logMAR视力提高了0.20 ± 0.24 (0-0.8)（P < 0.001），安慰剂组提高了0.08 ± 0.15 (0-0.7)（P = 0.01）；氟西汀组的平均logMAR视力提高幅度显著高于安慰剂组（P = 0.04）。研究结束时，氟西汀组的平均视力（0.36 ± 0.21 log MAR）优于安慰剂组（0.43 ± 0.35 log MAR）。在VEP参数中，两组的N75振幅与基线相比均无显著变化，但两组之间的变化在统计学上有显著差异（P = 0.05）；氟西汀组的N135潜伏期与基线相比有所改善（P = 0.03）：结论：在我们的研究队列中，氟西汀治疗成人弱视比安慰剂更能改善视力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.