Intracranial aneurysm stiffness assessment using 4D Flow MRI

IF 3 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuroradiology Pub Date : 2024-09-19 DOI:10.1016/j.neurad.2024.101221

Satoshi Koizumi , Taichi Kin , Tetsuro Sekine , Satoshi Kiyofuji , Motoyuki Umekawa , Nobuhito Saito

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引用次数: 0

Abstract

Background

Although arterial stiffness is known as a biomarker for cardiovascular events and stroke, there is limited information in the literature regarding the stiffness of intracranial aneurysms. In this study, we aim to assess the stiffness of intracranial aneurysms using 4D Flow MRI.

Methods

A total of 27 aneurysms in 25 patients with internal carotid artery aneurysms were included in this study. Using 4D Flow MRI, we measured the arterial pulse wave form during a cardiac cycle at planes proximal and distal to the target aneurysm. The damping of these waveforms through the aneurysm was defined as the aneurysm damping index (ADI) and compared to the contralateral side. We also investigated the clinical factors related to the ADI.

Results

ADI assessment was successful in all cases. The average ADI was 1.18±0.28, which was significantly larger than 1.0 (P = 0.0027 [t-test]). The ADI on the aneurysm side was larger than on the contralateral side (1.19±0.30 vs 1.05±0.17, P = 0.029 [t-test]). On multivariate analysis, the use of beta-blockers (β=0.46, P = 0.015) and smoking history (β=-0.22, P = 0.024) showed a significant correlation with ADI.

Conclusion

We have proposed a novel method to observe arterial pulse wave dumping through intracranial aneurysm using 4D Flow MRI. The damping can be quantitatively observed, and the ADI has correlations with clinical factors such as antihypertensive drugs and smoking. Further studies should focus more on evaluating aneurysm stiffness and its clinical applications.

Abstract Image

查看原文本刊更多论文

利用 4D 流式磁共振成像评估颅内动脉瘤的硬度。

背景：尽管动脉僵化被认为是心血管事件和中风的生物标志物，但有关颅内动脉瘤僵化的文献资料却很有限。在这项研究中，我们旨在利用四维流磁共振成像技术评估颅内动脉瘤的硬度：本研究共纳入了 25 名颈内动脉瘤患者的 27 个动脉瘤。通过四维血流磁共振成像，我们测量了目标动脉瘤近端和远端平面在一个心动周期内的动脉脉搏波形。这些波形通过动脉瘤的阻尼被定义为动脉瘤阻尼指数（ADI），并与对侧进行比较。我们还调查了与 ADI 相关的临床因素：所有病例的 ADI 评估都很成功。平均 ADI 为 1.18±0.28，明显大于 1.0（P=0.0027 [t-检验]）。动脉瘤一侧的 ADI 大于对侧（1.19±0.30 vs 1.05±0.17，P=0.029 [t-test]）。多变量分析显示，使用β-受体阻滞剂（β=0.46，P=0.015）和吸烟史（β=-0.22，P=0.024）与 ADI 有显著相关性：我们提出了一种利用四维流磁共振成像观察动脉脉搏波通过颅内动脉瘤倾泻的新方法。可以定量观察阻尼，ADI 与抗高血压药物和吸烟等临床因素相关。进一步的研究应更侧重于评估动脉瘤的硬度及其临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroradiology 医学-核医学

CiteScore

6.10

自引率

5.70%

发文量

142

审稿时长

6-12 weeks

期刊介绍： The Journal of Neuroradiology is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of diagnostic and Interventional neuroradiology, translational and molecular neuroimaging, and artificial intelligence in neuroradiology. The Journal of Neuroradiology considers for publication articles, reviews, technical notes and letters to the editors (correspondence section), provided that the methodology and scientific content are of high quality, and that the results will have substantial clinical impact and/or physiological importance.