Effects of Acute Hypocapnia on Postural Standing Balance Measured by Sharpened Romberg Testing (SRT) in Healthy Subjects.

IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Wilderness & Environmental Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-16 DOI:10.1177/10806032241282320
Ryan Dunn, Jan Stepanek, Richard Eboka, Gaurav N Pradhan
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引用次数: 0

Abstract

Introduction: The sharpened Romberg test (SRT) is a physical maneuver that has been used to identify ataxia in individuals in resource-limited settings. Previous research has suggested that performance on balance testing may be affected by hypocapnia. In this study, we sought to determine whether acute hyperventilation-induced hypocapnia affects performance on the SRT at 501 meters above sea level.

Methods: We recruited 22 healthy subjects. Each subject performed a baseline SRT. Subjects were then asked to hyperventilate to the point of hypocapnia, confirmed by measurement with a capnometer. Subjects were then asked to re-perform SRT. The primary endpoint was time to loss of balance, measured as time-to-stepout.

Results: Time-to-stepout (TTS) on SRT at baseline had a mean ± standard deviation of 101 ± 117 s. In the hypocapnic condition, TTS was reduced to 48 ± 68 s. TTS normalized to 121 ± 132 s after recovery to normal capnic levels. Time-to-stepout was found to be significantly shorter in the hypocapnic measurement compared to the baseline measurement (P = .0128). Statistical analysis was conducted using one-tailed, paired sample T-tests using a P-value of < .05.

Conclusions: Our study found a statistically and clinically significant reduction in performance on a balance test (SRT) when exposed to acute hyperventilation-induced hypocapnia compared to a eucapnic control. Our results suggest that acute hypocapnia may contribute to neurological dysfunction independently of hypobaric hypoxia.

急性低碳酸血症对通过锐化朗伯格测试(SRT)测量的健康受试者站立姿势平衡的影响。
简介锐化朗伯格测试(SRT)是一种物理操作,用于在资源有限的环境中识别共济失调患者。以前的研究表明,平衡测试的表现可能会受到低碳酸血症的影响。在本研究中,我们试图确定急性过度换气引起的低碳酸血症是否会影响海拔 501 米处的 SRT 表现:我们招募了 22 名健康受试者。每个受试者都进行了基线 SRT。然后,要求受试者过度换气至低碳酸血症程度,并用血压计进行测量确认。然后要求受试者重新进行 SRT。主要终点是失去平衡的时间,以 "步出时间"(time-to-stepout)来衡量:结果:基线 SRT 的失步时间(TTS)的平均值(± 标准偏差)为 101±117 秒。在低碳酸血症条件下,TTS 缩短至 48 ± 68 秒。恢复到正常血气水平后,TTS 恢复正常,为 121 ± 132 秒。与基线测量值相比,发现低碳酸血症测量值的步出时间明显缩短(P = .0128)。统计分析采用单尾配对样本 T 检验,P 值为结论:我们的研究发现,与通风良好的对照组相比,暴露于急性过度换气引起的低碳酸血症时,平衡测试(SRT)的成绩会出现统计学和临床上的显著下降。我们的研究结果表明,急性低碳酸血症可能会导致神经功能障碍,而与低压缺氧无关。
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来源期刊
Wilderness & Environmental Medicine
Wilderness & Environmental Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.10
自引率
7.10%
发文量
96
审稿时长
>12 weeks
期刊介绍: Wilderness & Environmental Medicine, the official journal of the Wilderness Medical Society, is the leading journal for physicians practicing medicine in austere environments. This quarterly journal features articles on all aspects of wilderness medicine, including high altitude and climbing, cold- and heat-related phenomena, natural environmental disasters, immersion and near-drowning, diving, and barotrauma, hazardous plants/animals/insects/marine animals, animal attacks, search and rescue, ethical and legal issues, aeromedial transport, survival physiology, medicine in remote environments, travel medicine, operational medicine, and wilderness trauma management. It presents original research and clinical reports from scientists and practitioners around the globe. WEM invites submissions from authors who want to take advantage of our established publication''s unique scope, wide readership, and international recognition in the field of wilderness medicine. Its readership is a diverse group of medical and outdoor professionals who choose WEM as their primary wilderness medical resource.
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