Time course of remnant cholesterol and the risk of heart failure.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xiaoxue Liu, Yijun Zhang, Xue Tian, Qin Xu, Xue Xia, Shuohua Chen, Fen Liu, Shouling Wu, Anxin Wang
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引用次数: 0

Abstract

Background and aim: Previous studies have shown that remnant cholesterol (RC) was associated with heart failure (HF). However, lack of evidence regarding the long-term trend of RC with HF risk. We aimed to investigate the association between cumulative RC exposure with incident HF and to further explore the modulating effects of the time course of RC accumulation.

Methods and results: We enrolled 41,168 participants free of CVD from the Kailuan Study who completed the first three health examinations from 2006 to 2010. Cumulative RC exposure included cumulative RC and time-weighted cumulative RC. The combination of cumulative RC and RC slope over time was characterized as the time course of RC accumulation. Multivariable adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for HF risk. We also considered non-HF-related death as a competing event by performing competing risk models as a sensitivity analysis. During 8.84 years, 839 participants developed HF events. Cumulative RC exposure increased the HF risk, with HRs for cumulative RC of 1.72 (1.41-2.10) and for time-averaged cumulative RC of 1.54 (1.25-1.89). There was a nonlinear relationship between cumulative RC exposure and HF risk. Participants with higher cumulative RC and negative slope had the highest HF risk (HR, 1.46; 95% CI, 1.16-1.83).

Conclusions: Both cumulative long-term exposure and the time course of RC accumulation were associated with HF risk. Early RC accumulation resulted in a greater increase in risk compared to later accumulation. This finding suggests that long-term exposure to RC may be useful in identifying individuals at high risk of developing HF and highlights the need for early initiation of appropriate RC control to prevent or reduce incident HF.

残余胆固醇与心力衰竭风险的时间进程。
背景和目的:以往的研究表明,残余胆固醇(RC)与心力衰竭(HF)有关。然而,缺乏有关残余胆固醇与心力衰竭风险长期趋势的证据。我们的目的是研究累积 RC 暴露与高血压发病之间的关系,并进一步探讨 RC 累积时间过程的调节作用:我们从开滦研究中招募了 41168 名无心血管疾病的参与者,他们在 2006 年至 2010 年期间完成了前三次健康检查。累积 RC 暴露包括累积 RC 和时间加权累积 RC。随着时间的推移,累积 RC 和 RC 斜率的组合被称为 RC 累积的时间过程。我们使用多变量调整后的 Cox 比例危险模型来计算 HF 风险的危险比 (HR) 和 95% 置信区间 (CI)。作为一项敏感性分析,我们还通过执行竞争风险模型将非心房颤动相关死亡视为竞争事件。在 8.84 年的时间里,839 名参与者发生了心房颤动事件。累积 RC 暴露增加了心房颤动风险,累积 RC 的 HR 值为 1.72(1.41-2.10),时间平均累积 RC 的 HR 值为 1.54(1.25-1.89)。累积 RC 暴露与高频风险之间存在非线性关系。累积 RC 较高且负斜率的参与者患高血压的风险最高(HR,1.46;95% CI,1.16-1.83):结论:长期累积RC暴露和RC累积的时间过程都与心房颤动风险有关。结论:RC 的长期累积暴露和累积时间均与高血压风险有关,早期 RC 累积导致的风险增加幅度大于后期累积。这一发现表明,长期暴露于 RC 可能有助于识别罹患心房颤动的高风险人群,并强调需要尽早开始适当的 RC 控制,以预防或减少心房颤动的发生。
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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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