Fatty acids profile in pregnancies affected by neural tube defects.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-23 DOI:10.1017/S2040174424000278

Kaouther Nasri, Hana Fenina, Salma Kloula Ben Ghorbal, Dhouha Maamer, Nadia Ben Jamaa, Moncef Feki, Soumeya Siala Gaigi

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引用次数: 0

Abstract

This study aimed to determine if maternal fatty acids (FA) levels during pregnancy are associated with the occurrence of neural tube defects (NTDs) and to explore the correlation between FA and maternal vitamin D, homocysteine, vitamin B₁₂, and folate in cases. Plasma FA composition was assessed using capillary gas chromatography. Comparisons between cases and controls were performed by independent samples t-test for continuous variables. Cases had significantly higher levels of heptadecanoic acid, linolelaidic acid, and arachidonic acid (ARA):(eicosapentaenoic acid+docosahexaenoic acid) ratio than controls (p < 0.05). Nervonic acid, ARA, adrenic acid, eicosapentaenoic acid, docosahexaenoic acid, and omega-3 polyunsaturated fatty acids (n-3 PUFA) levels were significantly lower in cases (p < 0.05). Maternal 25-hydroxyvitamin D (25(OH)D) levels were positively correlated with maternal polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids. RBC folate levels were negatively correlated with n-3 PUFA.Further research is required to clarify the association of FA metabolism with NTDs.

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受神经管缺陷影响的孕妇的脂肪酸概况。

本研究旨在确定孕期母体脂肪酸（FA）水平是否与神经管畸形（NTD）的发生有关，并探讨FA与母体维生素D、同型半胱氨酸、维生素B12和叶酸之间的相关性。使用毛细管气相色谱法评估血浆中的脂肪酸组成。病例与对照组之间的比较采用连续变量的独立样本 t 检验。病例的十七酸、亚油酸和花生四烯酸（ARA）：（二十碳五烯酸+二十二碳六烯酸）比值明显高于对照组（P < 0.05）。病例的神经氨酸、ARA、肾上腺酸、二十碳五烯酸、二十二碳六烯酸和欧米伽-3 多不饱和脂肪酸（n-3 PUFA）水平明显低于对照组（p < 0.05）。母体 25- 羟维生素 D（25(OH)D）水平与母体多不饱和脂肪酸和ω-6 多不饱和脂肪酸呈正相关。需要开展进一步研究，以明确脂肪酸代谢与 NTD 的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Developmental Origins of Health and Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

0.00%

发文量

145

审稿时长

6-12 weeks

期刊介绍： JDOHaD publishes leading research in the field of Developmental Origins of Health and Disease (DOHaD). The Journal focuses on the environment during early pre-natal and post-natal animal and human development, interactions between environmental and genetic factors, including environmental toxicants, and their influence on health and disease risk throughout the lifespan. JDOHaD publishes work on developmental programming, fetal and neonatal biology and physiology, early life nutrition, especially during the first 1,000 days of life, human ecology and evolution and Gene-Environment Interactions. JDOHaD also accepts manuscripts that address the social determinants or education of health and disease risk as they relate to the early life period, as well as the economic and health care costs of a poor start to life. Accordingly, JDOHaD is multi-disciplinary, with contributions from basic scientists working in the fields of physiology, biochemistry and nutrition, endocrinology and metabolism, developmental biology, molecular biology/ epigenetics, human biology/ anthropology, and evolutionary developmental biology. Moreover clinicians, nutritionists, epidemiologists, social scientists, economists, public health specialists and policy makers are very welcome to submit manuscripts. The journal includes original research articles, short communications and reviews, and has regular themed issues, with guest editors; it is also a platform for conference/workshop reports, and for opinion, comment and interaction.