Do dynamic changes in haematological and biochemical parameters predict mortality in critically ill COVID-19 patients?

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care Pub Date : 2024-09-05 DOI:10.3233/THC-241006

Milka Jandric, Biljana Zlojutro, Danica Momcicevic, Sasa Dragic, Tijana Kovacevic, Vlado Djajic, Milos P Stojiljkovic, Dragana Loncar-Stojiljkovic, Ranko Skrbic, Dragan M Djuric, Pedja Kovacevic

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引用次数: 0

Abstract

Background: Critically ill COVID-19 patients are usually subjected to clinical, laboratory, and radiological diagnostic procedures resulting in numerous findings. Utilizing these findings as indicators for disease progression or outcome prediction is particularly intriguing.

Objectives: Exploring the significance of dynamic changes in haematological and biochemical parameters in predicting the mortality of critically ill COVID-19 patients.

Methods: The present study was a prospective and observational study involving mechanically ventilated 75 critically ill adult COVID-19 patients with hypoxemic respiratory failure. The collected data included baseline patient characteristics, treatment options, outcome, and laboratory findings at admission and 7 days after. The dynamics of the obtained findings were compared between survivors and non-survivors.

Results: The 28-day survival rate was 61.3%. In the group of non-survivors significant dynamic changes were found for C-reactive protein (p= 0.001), interleukin-6 (p< 0.001), lymphocyte (p= 0.003), neutrophil-lymphocyte ratio (p= 0.003), platelets (p< 0.001), haemoglobin (p< 0.001), iron (p= 0.012), and total iron-binding capacity (p< 0.001). Statistically significant changes over time were found for ferritin (p= 0.010), D-dimer (p< 0.001), hs-troponin T (p< 0.002), lactate dehydrogenase (p= 0.001), glucose (p= 0.023), unsaturated iron-binding capacity (p= 0.008), and vitamin D (p< 0.001).

Conclusion: The dynamic changes in inflammatory, haematological and biochemical parameters can predict disease severity, and outcome.

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血液和生化指标的动态变化能否预测 COVID-19 重症患者的死亡率？

背景：COVID-19重症患者通常需要接受临床、实验室和放射诊断程序，从而得出许多结果。利用这些结果作为疾病进展或预后的指标尤其引人关注：探索血液和生化指标的动态变化在预测 COVID-19 重症患者死亡率方面的意义：本研究是一项前瞻性观察研究，涉及 75 名机械通气的低氧血症呼吸衰竭 COVID-19 重症成人患者。收集的数据包括患者的基线特征、治疗方案、结果以及入院时和入院 7 天后的实验室检查结果。对幸存者和非幸存者所获结果的动态变化进行了比较：结果：28 天存活率为 61.3%。在非幸存者组中，C 反应蛋白（p= 0.001）、白细胞介素-6（p< 0.001）、淋巴细胞（p= 0.003）、中性粒细胞-淋巴细胞比率（p= 0.003）、血小板（p< 0.001）、血红蛋白（p< 0.001）、铁（p= 0.012）和总铁结合能力（p< 0.001）均有显著的动态变化。铁蛋白（p= 0.010）、D-二聚体（p< 0.001）、hs-肌钙蛋白 T（p< 0.002）、乳酸脱氢酶（p= 0.001）、葡萄糖（p= 0.023）、不饱和铁结合能力（p= 0.008）和维生素 D（p< 0.001）随时间的变化具有统计学意义：炎症、血液学和生化参数的动态变化可预测疾病的严重程度和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

期刊介绍： Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).