Bridging the care gap: radiation therapy in elderly and frail cancer patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI:10.1097/SPC.0000000000000727

Caroline Hircock, Shing Fung Lee, Srinivas Raman, Elizabeth Chuk, Adrian W Chan, Edward Chow, Henry C Y Wong

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引用次数: 0

Abstract

Purpose of review: This review aims to address the gap in radiation therapy (RT) care for elderly cancer patients. It will discuss the barriers to implementing effective RT in elderly and frail patients with a focus on breast cancer and metastatic settings.

Recent findings: Recent studies indicate that SBRT provides better pain control for bone metastases compared to cEBRT, but elderly patients are underrepresented in these trials. Evidence on the effectiveness of geriatric assessment tools in predicting RT tolerance and toxicity is mixed, with some studies showing a correlation while others do not. Comprehensive geriatric assessments, though promising, are often impractical due to time and resource constraints.

Summary: There is a critical need for more inclusive research to better understand the risks and benefits of RT in elderly patients. Developing streamlined geriatric assessment tools and integrating them into clinical practice can enhance treatment personalization. Future studies should prioritize elderly populations to generate robust data, thereby improving RT outcomes and quality of life for this growing patient group.

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缩小护理差距：年老体弱癌症患者的放射治疗。

综述目的：本综述旨在探讨老年癌症患者放射治疗（RT）护理方面的差距。它将讨论对老年和体弱患者实施有效 RT 的障碍，重点关注乳腺癌和骨转移：最近的研究表明，与 cEBRT 相比，SBRT 能更好地控制骨转移患者的疼痛，但老年患者在这些试验中的代表性不足。老年评估工具在预测 RT 耐受性和毒性方面的有效性证据不一，有些研究显示存在相关性，有些则没有。全面的老年评估虽然很有前景，但由于时间和资源的限制，往往并不现实。开发简化的老年评估工具并将其融入临床实践，可以提高治疗的个性化程度。未来的研究应优先考虑老年群体，以生成可靠的数据，从而改善这一日益增长的患者群体的 RT 治疗效果和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.