Predicting survival in sepsis: The prognostic value of NLR and BAR ratios.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-05 DOI:10.3233/THC-241415

Xuwei He, Tianzheng Lou, Ning Zhang, Bin Zhu, Danyi Zeng, Hua Chen

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引用次数: 0

Abstract

Background: Due to the high-risk nature of sepsis, emergency departments urgently need a simple evaluation method to assess the degree of inflammation and prognosis in sepsis patients, providing a reference for diagnosis and treatment.

Objective: To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) combined with the blood urea nitrogen-to-serum albumin ratio (BAR) in sepsis.

Methods: A total of 377 sepsis patients admitted to Lishui People's Hospital from June 2022 to June 2023 were selected as the study subjects. Based on their prognosis, they were divided into a survival group (255 cases) and a death group (82 cases). The clinical data of the two groups were compared. Multivariate logistic analysis was used to identify factors influencing sepsis prognosis, and ROC curve analysis was used to assess the predictive efficacy of NLR, BAR, and their combination.

Results: Compared with survivors, non-survivors had higher NLR and BAR, with statistically significant differences (p< 0.05). After adjusting for confounding factors, NLR (OR = 1.052) and BAR (OR = 1.095) were found to be independent prognostic factors for sepsis patients (both p< 0.05). The AUC of NLR combined with BAR was 0.798 (95% CI 0.745-0.850, p< 0.05), higher than the AUC of NLR alone (0.776) and BAR alone (0.701).

Conclusions: The combination of NLR and BAR has a high predictive value for the prognosis of sepsis patients. Its simple calculation makes it particularly suitable for use in emergency departments.

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预测败血症患者的存活率：NLR 和 BAR 比率的预后价值。

背景：由于败血症的高危性，急诊科急需一种简单的评估方法来评估败血症患者的炎症程度和预后，为诊断和治疗提供参考：由于败血症的高危险性，急诊科急需一种简单的评估方法来评估败血症患者的炎症程度和预后，为诊断和治疗提供参考：研究脓毒症患者中性粒细胞与淋巴细胞比值（NLR）结合血尿素氮与血清白蛋白比值（BAR）的预后价值：方法：选取2022年6月至2023年6月期间丽水市人民医院收治的377例败血症患者作为研究对象。根据预后分为生存组（255 例）和死亡组（82 例）。对两组患者的临床数据进行比较。采用多变量逻辑分析确定影响败血症预后的因素，并采用 ROC 曲线分析评估 NLR、BAR 及其组合的预测效果：与幸存者相比，非幸存者的 NLR 和 BAR 均较高，差异有统计学意义（P< 0.05）。调整混杂因素后发现，NLR（OR = 1.052）和 BAR（OR = 1.095）是脓毒症患者的独立预后因素（均 p< 0.05）。NLR结合BAR的AUC为0.798（95% CI 0.745-0.850，p< 0.05），高于单独NLR的AUC（0.776）和单独BAR的AUC（0.701）：结论：NLR 和 BAR 的组合对脓毒症患者的预后具有很高的预测价值。结论：NLR 和 BAR 的组合对脓毒症患者的预后具有很高的预测价值，其计算简单，特别适合急诊科使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.