Large Vessel Vasculitis in a Patient Receiving G-CSF: A Possible Differential for Fever of Unknown Origin.

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Indian Journal of Nuclear Medicine Pub Date : 2024-05-01 Epub Date: 2024-08-17 DOI:10.4103/ijnm.ijnm_138_23
Raza Abbas Mahdi, Venkata Subramanian Krishnaraju, Bhagwant Rai Mittal, Harmandeep Singh, Rajender Kumar, Gaurav Prakash
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引用次数: 0

Abstract

Large vessel vasculitis is a known but rare side effect of granulocyte colony-stimulating factor (G-CSF) therapy. We report a case of adenocarcinoma lung with pleural infiltration and mediastinal lymphadenopathy, who was treated with neoadjuvant chemotherapy and pegylated G-CSF. After three cycles, he developed a fever. He underwent F-18 fludeoxyglucose (FDG) positron emission tomography computed tomography for fever of unkwnown origin evaluation, which revealed a response to chemotherapy along with the appearance of FDG avid mural thickening in a few large arteries, suggesting a diagnosis of G-CSF-induced large vessel vasculitis.

接受 G-CSF 治疗患者的大血管炎:不明原因发热的一种可能鉴别诊断。
大血管炎是粒细胞集落刺激因子(G-CSF)治疗的一种已知但罕见的副作用。我们报告了一例肺腺癌伴胸膜浸润和纵隔淋巴结病的患者,他接受了新辅助化疗和聚乙二醇 G-CSF 治疗。三个周期后,他出现了发热。他接受了 F-18 氟脱氧葡萄糖(FDG)正电子发射计算机断层扫描,以评估不明原因的发热,结果显示他对化疗有反应,同时在几条大动脉中出现了 FDG 阳性壁层增厚,这提示了 G-CSF 引起的大血管炎的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Nuclear Medicine
Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.70
自引率
0.00%
发文量
46
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