Abnormal Vestibulo-Ocular Reflex Function Correlates with Balance and Gait Impairment in People with Multiple Sclerosis.

IF 2.1 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Audiology Research Pub Date : 2024-09-09 DOI:10.3390/audiolres14050067

Marco Tramontano, Laura Casagrande Conti, Amaranta Soledad Orejel Bustos, Nicola Ferri, Tommaso Lelli, Ugo Nocentini, Maria Grazia Grasso, Andrea Turolla, Paolo Pillastrini, Leonardo Manzari

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Abstract

Background: Multiple Sclerosis (MS) is the most prevalent autoimmune neurological condition in the world, leading to a wide variety of symptoms, including balance disorders.

Objective: To evaluate the angular vestibulo-ocular reflex (aVOR) of all six semicircular canals (SCCs) through Head Impulse (HIMP) and Suppression HIMP (SHIMP) paradigms and any correlations with clinical balance scales.

Methods: All participants were assessed using the Expanded Disability Status Scale (EDSS), Berg Balance Scale (BBS), and Mini-BESTest (MBT). Vestibular function was measured by video Head Impulse Test (vHIT), obtaining aVOR gain for each SSC.

Results: Twenty-seven PwMS (mean age 47.93 ± 8.51 years old, 18 females) were recruited. Most of the patients (81.48%) presented abnormal aVOR gains for at least one SSC. A moderate to strong correlation between aVOR gains of the left anterior SSC and, respectively, the MBT and the BBS was found. The subgroup analysis, based on the EDSS class, confirmed the correlation with the BBS in the patients with the most significant disability.

Conclusions: People with MS may present impairments of the aVOR in one or more semicircular canals. The aVOR gain impairment of the vertical semicircular canals correlates with balance and gait disorders identified through clinical scales in PwMS.

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前庭-眼球反射功能异常与多发性硬化症患者的平衡和步态障碍有关。

背景：多发性硬化症（MS）是世界上最常见的自身免疫性神经疾病：多发性硬化症（MS）是世界上最常见的自身免疫性神经疾病，会导致包括平衡失调在内的多种症状：通过头部冲动（HIMP）和抑制HIMP（SHIMP）范式评估所有六个半规管（SCC）的角前庭反射（aVOR）以及与临床平衡量表的相关性：使用扩展残疾状况量表（EDSS）、伯格平衡量表（BBS）和迷你测试（MBT）对所有参与者进行评估。前庭功能通过视频头脉冲测试（vHIT）进行测量，获得每个 SSC 的 VOR 增益：共招募了 27 名 PwMS（平均年龄 47.93 ± 8.51 岁，18 名女性）。大多数患者（81.48%）至少有一个 SSC 的 aVOR 增益出现异常。研究发现，左前 SSC 的 aVOR 增益分别与 MBT 和 BBS 之间存在中度到高度的相关性。根据 EDSS 分级进行的亚组分析证实，残疾程度最严重的患者与 BBS 存在相关性：结论：多发性硬化症患者可能会出现一个或多个半规管的aVOR受损。结论：多发性硬化症患者可能会出现一个或多个半规管的aVOR增益障碍，垂直半规管的aVOR增益障碍与通过临床量表确定的PwMS患者的平衡和步态障碍相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Audiology Research AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-

CiteScore

2.30

自引率

23.50%

发文量

审稿时长

11 weeks

期刊介绍： The mission of Audiology Research is to publish contemporary, ethical, clinically relevant scientific researches related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear that can be used by clinicians, scientists and specialists to improve understanding and treatment of patients with audiological and neurotological disorders.