[Current research status of virus-like particle vaccine].

Q3 Medicine

中华预防医学杂志 Pub Date : 2024-09-06 DOI:10.3760/cma.j.cn112150-20231123-00366

L Zhang, Y F Yang, X Ma, Y F Zhang, Y Wang

引用次数: 0

Abstract

Virus-like particles (VLPs) are self-assembled protein nanoparticles with repetitive antigen epitopes, which can stimulate immune response and do not contain viral genetic materials. VLPs has important research value and application potential in vaccine development, targeted drug delivery and bioengineering materials. In this review, the mechanism of VLPs vaccine induced immune responses is discussed. The existing VLPs expression systems are summarized. The research progress of VLPs vaccine in prevention and treatment of virus infection are summarized. This review provides general reference and guidance for the design and development of antiviral VLPs vaccine.

查看原文本刊更多论文

[病毒样颗粒疫苗的研究现状]。

病毒样颗粒（VLPs）是一种具有重复抗原表位的自组装蛋白纳米颗粒，可激发免疫反应，不含病毒遗传物质。VLPs 在疫苗开发、靶向给药和生物工程材料等方面具有重要的研究价值和应用潜力。本综述讨论了 VLPs 疫苗诱导免疫反应的机制。总结了现有的 VLPs 表达系统。总结了 VLPs 疫苗在预防和治疗病毒感染方面的研究进展。本综述为设计和开发抗病毒 VLPs 疫苗提供了一般参考和指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.