[Association of serum 25(OH)D₃ with cardiovascular risk-related indicators: cross-sectional analysis of NHANES].

Q3 Medicine

中华预防医学杂志 Pub Date : 2024-09-06 DOI:10.3760/cma.j.cn112150-20240519-00403

Y X Pan, Y C Fu, H Chen, M Y Zhao

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引用次数: 0

Abstract

This study investigated the association between serum 25(OH)D₃ levels and cardiovascular risk-related indicators. 4 727 participants aged 20 and above from the National Health and Nutrition Examination Survey 2015-2018 database were enrolled. Body mass index, hypersensitive C-reactive protein, high density lipoprotein cholesterol, systolic blood pressure, waist-height ratio, and total cholesterol were selected as the research indicators. Weighted multiple linear regression models, subgroup analyses, smooth curve fitting, and saturation threshold effect analyses were employed to explore the relationship between serum 25(OH)D₃ and these indicators. The results showed that after full adjustment for covariates, every 1 nmol/L increase in serum 25(OH)D₃, the changes in β (95%CI) values for body mass index(BMI), hypersensitive C-reactive protein(hs-CRP), systolic blood pressure(SBP), waist-height ratio(WHtR), high density lipoprotein cholesterol(HDL-C), and total cholesterol(TC) were -0.05 (-0.06, -0.04) kg/m², -0.01 (-0.02, -0.01) mg/L, -0.02 (-0.04, -0.01) mmHg, -0.000 7 (-0.000 8, -0.000 6), 0.10 (0.08, 0.11) mg/dl, and 0.08 (0.04, 0.12) mg/dl, respectively. Female participants were more sensitive to changes in serum 25(OH)D₃, while participants aged 60 and above were relatively less sensitive. The relationship between serum 25(OH)D₃ and these indicators partially exhibited nonlinear patterns across different gender and age subgroups. The saturation threshold effect analysis revealed 8 meaningful inflection points. In summary, vitamin D has a close association with cardiovascular risk-related indicators.

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[血清 25（OH）D3 与心血管风险相关指标的关系：NHANES 横截面分析]。

本研究调查了血清25（OH）D3水平与心血管风险相关指标之间的关系。4 727 名 20 岁及以上的参与者来自 2015-2018 年全国健康与营养调查数据库。选取体重指数、超敏C反应蛋白、高密度脂蛋白胆固醇、收缩压、腰高比和总胆固醇作为研究指标。采用加权多元线性回归模型、亚组分析、平滑曲线拟合、饱和阈值效应分析等方法探讨血清25（OH）D3与上述指标的关系。结果显示，在充分调整协变量后，血清 25（OH）D3 每增加 1 nmol/L，体重指数（BMI）、超敏 C 反应蛋白（hs-CRP）、收缩压（SBP）、腰围-身高比（WHtR）、高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）的 β 值（95%CI）变化分别为-0.对高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）的影响分别为-0.05 (-0.06, -0.04) kg/m2、-0.01 (-0.02, -0.01) mg/L、-0.02 (-0.04, 0.01) mmHg、-0.000 7 (-0.000 8, -0.000 6)、0.10 (0.08, 0.11) mg/dl 和 0.08 (0.04, 0.12) mg/dl。女性参与者对血清 25（OH）D3 的变化更为敏感，而 60 岁及以上的参与者则相对不那么敏感。在不同性别和年龄分组中，血清 25（OH）D3 与这些指标之间的关系部分呈现非线性模式。饱和阈值效应分析显示了 8 个有意义的拐点。总之，维生素 D 与心血管风险相关指标密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.