Alperen Sozer, Mustafa Caglar Sahin, Batuhan Sozer, Ekin Sozer, Pelin Bayik, Nil Tokgoz, Hakan Emmez, Memduh Kaymaz, Mesut Emre Yaman
{"title":"Radioneuromodulation of Nucleus Accumbens for Addiction: The First Animal Study.","authors":"Alperen Sozer, Mustafa Caglar Sahin, Batuhan Sozer, Ekin Sozer, Pelin Bayik, Nil Tokgoz, Hakan Emmez, Memduh Kaymaz, Mesut Emre Yaman","doi":"10.1016/j.wneu.2024.09.043","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Addiction is a serious spiral where negative events or relationships triggers a craving even when the situation is caused by the addiction in the first place. Nucleus Accumbens (NAcc) is identified as an important hub for the neural pathways involved in the addictive behavior. Stimulation of this structure was demonstrated to be beneficial for addiction previously, but radioneuromodulation was never investigated until today. This study aimed to investigate if radioneuromodulation of the nucleus accumbens has any effect on alcohol addiction.</p><p><strong>Methods: </strong>An addiction model was employed on 36 Long-Evans Rats (18 females/18 males), via a two-bottle intermittent access protocol and the trial group received 100 Gy of gamma irradiation to their bilateral NAcc. Rats were followed up for an additional 15 weeks. Multiple sets of a behavioral test battery, a 4-week abstinence period and quinine adulteration challenges were employed to evaluate responses.</p><p><strong>Results: </strong>The experiment showed that the intervention reduced alcohol preference in the presence of aversive stimuli in female rats, compared to the non-irradiated controls, as the trial group showed 9.83-point decrease in alcohol preference rate under high dose quinine adulteration compared to the baseline, whereas the control group did not show any decrease. Also there were implications of additional benefits regarding weight control in females and behavioral tests in males. No evident adverse effect was observed with the treatment.</p><p><strong>Conclusions: </strong>This study indicates that nucleus accumbens radioneuromodulation, although not significantly affecting baseline consumption, reduces intake when an aversive stimulus is involved, implying improved self-control.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.wneu.2024.09.043","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Addiction is a serious spiral where negative events or relationships triggers a craving even when the situation is caused by the addiction in the first place. Nucleus Accumbens (NAcc) is identified as an important hub for the neural pathways involved in the addictive behavior. Stimulation of this structure was demonstrated to be beneficial for addiction previously, but radioneuromodulation was never investigated until today. This study aimed to investigate if radioneuromodulation of the nucleus accumbens has any effect on alcohol addiction.
Methods: An addiction model was employed on 36 Long-Evans Rats (18 females/18 males), via a two-bottle intermittent access protocol and the trial group received 100 Gy of gamma irradiation to their bilateral NAcc. Rats were followed up for an additional 15 weeks. Multiple sets of a behavioral test battery, a 4-week abstinence period and quinine adulteration challenges were employed to evaluate responses.
Results: The experiment showed that the intervention reduced alcohol preference in the presence of aversive stimuli in female rats, compared to the non-irradiated controls, as the trial group showed 9.83-point decrease in alcohol preference rate under high dose quinine adulteration compared to the baseline, whereas the control group did not show any decrease. Also there were implications of additional benefits regarding weight control in females and behavioral tests in males. No evident adverse effect was observed with the treatment.
Conclusions: This study indicates that nucleus accumbens radioneuromodulation, although not significantly affecting baseline consumption, reduces intake when an aversive stimulus is involved, implying improved self-control.
期刊介绍:
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS