Cytokeratin expression by sarcomas does not indicate synovial origin in dogs.

IF 2.3 2区农林科学 Q2 PATHOLOGY

Veterinary Pathology Pub Date : 2024-09-16 DOI:10.1177/03009858241279135

Annalisa C Wager, Cary Springer, Rebecca Bergee, Linden E Craig

{"title":"Cytokeratin expression by sarcomas does not indicate synovial origin in dogs.","authors":"Annalisa C Wager, Cary Springer, Rebecca Bergee, Linden E Craig","doi":"10.1177/03009858241279135","DOIUrl":null,"url":null,"abstract":"Sarcoma samples from 33 dogs, 25 subcutaneous and 8 articular, were submitted for cytokeratin immunohistochemistry. Eight of the 25 subcutaneous sarcomas (32%) expressed cytokeratin in 1% to 50% of the neoplastic cells. Of the 7 articular sarcomas evaluated, 1 (14%) expressed cytokeratin in 10% of neoplastic cells. The Kaplan-Meier survival analysis showed that the mean overall survival of dogs with subcutaneous sarcomas (28.1 months [confidence interval [CI]:17.8, 38.4]) did not significantly differ from those with articular sarcomas (24.8 months [CI = 0.5, 29.0]). Overall survival of dogs with sarcomas (both locations combined) immunoreactive for cytokeratin (31.2 months [CI = 17.8, 44.6]) did not differ from those not immunoreactive for cytokeratin (22.0 months [CI = 8.4, 35.6]). Therefore, cytokeratin expression does not indicate synovial origin (P = .64) and neither sarcoma location (P = .76) nor cytokeratin expression (P = .53) affects patient overall survival in this small study. The use of cytokeratin immunohistochemistry is not helpful to determine synovial origin of sarcomas in dogs.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241279135"},"PeriodicalIF":2.3000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Pathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1177/03009858241279135","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Sarcoma samples from 33 dogs, 25 subcutaneous and 8 articular, were submitted for cytokeratin immunohistochemistry. Eight of the 25 subcutaneous sarcomas (32%) expressed cytokeratin in 1% to 50% of the neoplastic cells. Of the 7 articular sarcomas evaluated, 1 (14%) expressed cytokeratin in 10% of neoplastic cells. The Kaplan-Meier survival analysis showed that the mean overall survival of dogs with subcutaneous sarcomas (28.1 months [confidence interval [CI]:17.8, 38.4]) did not significantly differ from those with articular sarcomas (24.8 months [CI = 0.5, 29.0]). Overall survival of dogs with sarcomas (both locations combined) immunoreactive for cytokeratin (31.2 months [CI = 17.8, 44.6]) did not differ from those not immunoreactive for cytokeratin (22.0 months [CI = 8.4, 35.6]). Therefore, cytokeratin expression does not indicate synovial origin (P = .64) and neither sarcoma location (P = .76) nor cytokeratin expression (P = .53) affects patient overall survival in this small study. The use of cytokeratin immunohistochemistry is not helpful to determine synovial origin of sarcomas in dogs.

查看原文本刊更多论文

在狗身上，肉瘤中细胞角蛋白的表达并不表明源自滑膜。

对 33 只狗的肉瘤样本（25 只皮下肉瘤和 8 只关节肉瘤）进行了细胞角蛋白免疫组化。在 25 个皮下肉瘤中，有 8 个（32%）在 1%至 50%的肿瘤细胞中表达细胞角蛋白。在评估的 7 例关节肉瘤中，有 1 例（14%）在 10% 的肿瘤细胞中表达细胞角蛋白。卡普兰-米尔生存分析表明，皮下肉瘤患犬的平均总生存期（28.1 个月［置信区间［CI］：17.8，38.4］）与关节肉瘤患犬的平均总生存期（24.8 个月［CI = 0.5，29.0］）没有显著差异。对细胞角蛋白有免疫反应的肉瘤（两处均有）狗的总存活期（31.2 个月 [CI = 17.8, 44.6]）与对细胞角蛋白无免疫反应的狗的总存活期（22.0 个月 [CI = 8.4, 35.6]）没有差异。因此，在这项小型研究中，细胞角蛋白的表达并不表示滑膜起源（P = .64），肉瘤位置（P = .76）和细胞角蛋白表达（P = .53）都不会影响患者的总生存期。细胞角蛋白免疫组化无助于确定犬肉瘤的滑膜起源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Veterinary Pathology 农林科学-病理学

CiteScore

4.70

自引率

8.30%

发文量

审稿时长

2 months

期刊介绍： Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.