Pharmacokinetics and tissue residues of colistin following intravenous, and single and repeated oral dosing in domestic geese (Anser anser domesticus)

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Krzysztof Bourdo , Charbel Fadel , Mario Giorgi , Anna Gajda , Magdalena Bilecka , Amnart Poapolathep , Beata Łebkowska-Wieruszewska
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引用次数: 0

Abstract

Colistin, also known as polymyxin E, is a member of the polymyxin group of antibiotics. It is approved in Europe to treat enteric infections caused by Gram-negative bacteria, such as Escherichia coli, in poultry, although the similarity of infections between species make it likely used off-label in geese as well.This study investigated the pharmacokinetics and tissue residues of colistin in geese through in vivo experiments. The study involved longitudinal open studies on 16 healthy adult male geese, divided into three phases separated by one-month washout period. Geese were administered colistin via intravenous (IV, 1 mg/kg), single oral (PO, 30 mg/kg), and multiple oral (SID, 2.5 mg/kg for five consecutive days) routes, with blood samples drawn at specific intervals. Tissue samples were also collected at pre-assigned times for subsequent analysis. Colistin levels in geese plasma were quantified using a fully validated UHPLC-MS/MS method.
Plasma concentrations could be quantified up to 24 h for the single PO (n= 2) and IV (n= 4) routes, and up to 10 h (n= 6) from the last dose administered for the multiple PO route (n=6). The bioavailability was significantly low, averaging 3 %. The terminal half-life in geese was 2.18 h following IV administration, similar to values found in other avian species. Following IV administration, clearance and volume of distribution values were 0.11 mL⋅h⁻¹⋅g⁻¹ and 0.41 mL⋅g⁻¹, respectively. The body extraction ratio was low at 0.2 %, indicating minimal hepatic and renal elimination of colistin. Multiple oral doses showed no plasma accumulation, and tissue levels consistently remained below the maximum residue limit (MRL) set for food-producing animals. This study highlights the minimal systemic bioavailability and tissue penetration of colistin in geese, consistent with findings in other poultry and mammals. Future research should focus on intestinal colistin content in geese to optimize dosing strategies and minimize anti-microbial resistance.
家鹅(anser anser domesticus)静脉注射、单次口服和重复口服可乐定后的药代动力学和组织残留。
秋水仙素又称多粘菌素 E,是多粘菌素类抗生素的一种。本研究通过体内实验研究了可乐定在鹅体内的药代动力学和组织残留。该研究对 16 只健康的成年雄鹅进行了纵向开放式研究,分为三个阶段,中间间隔一个月的清洗期。鹅通过静脉注射(IV,1 毫克/千克)、单次口服(PO,30 毫克/千克)和多次口服(SID,2.5 毫克/千克,连续五天)途径服用可乐定,并在特定时间间隔抽取血液样本。此外,还在预先指定的时间采集组织样本进行后续分析。使用经过全面验证的 UHPLC-MS/MS 方法对鹅血浆中的可乐定水平进行定量。单次口服(2 只)和静脉注射(4 只)的血浆浓度可在 24 小时内定量,多次口服(6 只)的血浆浓度可在最后一次给药后 10 小时内定量。生物利用率明显偏低,平均为 3%。鹅静脉注射后的终末半衰期为 2.18 小时,与其他禽类物种的半衰期相似。静脉注射后,清除率和分布容积值分别为 0.11mL⋅hr-¹⋅g-¹ 和 0.41mL-g-¹。体内萃取率低至 0.2%,表明肝脏和肾脏对可乐定的清除率极低。多次口服表明血浆中没有积累,组织中的含量始终低于为食用动物设定的最大残留限量(MRL)。本研究强调了大肠杆菌素在鹅体内的最小全身生物利用度和组织渗透性,这与其他家禽和哺乳动物的研究结果一致。未来的研究应重点关注鹅肠道中的可乐定含量,以优化给药策略,最大限度地降低抗微生物耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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