Extracellular vesicles in kidney disease – A veterinary perspective

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Jack S. Lawson , Timothy L. Williams
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引用次数: 0

Abstract

Extracellular vesicles (EVs) are membrane bound vesicles secreted from cells into the extracellular space which have an emerging role in both normal kidney physiology and the pathophysiology of kidney injury, predominantly as mediators of intercellular communication. EVs contain proteins and RNA cargo which reflect their cell of origin and can be isolated from the urine of cats and dogs. The majority of urinary EVs (uEVs) originate from the kidney, and both the uEV proteome and transcriptome have been investigated as sources of biomarkers of kidney disease. In addition to their possible diagnostic role, EVs may also have therapeutic potential, and veterinary species have been used as models to demonstrate the efficacy of exogenous EVs derived from mesenchymal stromal cells in the treatment of acute kidney injury. Furthermore, bioengineered EVs may represent a novel vehicle for the administration of drugs or therapeutic nucleic acids in kidney disease. This article reviews the biological functions of EVs within the kidney, techniques for their isolation, and their potential use as biomarkers and therapeutic agents, with particular focus on the potential significance to veterinary patients.
肾病中的细胞外囊泡--兽医视角。
细胞外囊泡(EVs)是细胞分泌到细胞外空间的膜结合囊泡,在正常肾脏生理和肾脏损伤的病理生理学中都扮演着新的角色,主要是作为细胞间通信的媒介。EVs含有蛋白质和RNA,反映了它们的来源细胞,可以从猫和狗的尿液中分离出来。大多数尿液 EVs(uEVs)来自肾脏,uEV 蛋白质组和转录组已被研究为肾脏疾病的生物标志物来源。除了可能的诊断作用外,EVs 还可能具有治疗潜力,兽类已被用作模型来证明源自间充质基质细胞的外源性 EVs 在治疗急性肾损伤方面的疗效。此外,生物工程EVs可能是在肾脏疾病中施用药物或治疗性核酸的新型载体。本文综述了EVs在肾脏中的生物功能、EVs分离技术及其作为生物标记物和治疗剂的潜在用途,并特别关注其对兽医患者的潜在意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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