Relationship between functional status and fatigue after COVID-19 infection: a multicenter study from Türkiye.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-14 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5831

İpek Candemir, Pınar Ergün, Dicle Kaymaz, Mustafa Engin Şahin, İpek Özmen, Elif Yildirim, Aslı Görek Dilektaşli, Büşra Yiğitliler, Ayten Odabaş, Deniz Kizilirmak, Seçil Sari, Celalettin Korkmaz, Cantürk Taşçi, Yakup Arslan, Sema Savci, Buse Kahraman, Aylin Tanriverdi, Can Sevinç, Melda Sağlam, Deniz Inal Ince, Naciye Vardar Yağli, Ebru Kütükçü, Dilber Durmaz, Neslihan Durutürk, Gaye Ulubay, Lütfiye Kiliç, Benan Çağlayan, Aylin Moray, Sabri Serhan Olcay, Güven Özkaya

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引用次数: 0

Abstract

Background/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address..

Materials and methods: Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence of dyspnea, presence of cough, presence of sputum, and modified Medical Research Council, Post-COVID Functional Status (PCFS), Fatigue Severity Scale (FSS), and EQ-5D-5L Questionnaire scores were recorded.

Results: We enrolled 1095 patients, including 603 (55%) men and 492 (45%) women with a mean age of 50 ± 14 years. The most common chronic lung disease was COPD (11%) and 266 (29%) patients had nonpulmonary disease. The median time elapsed since COVID-19 diagnosis was 5 months; the hospitalization rate was 47%. The median PCFS grade was 1 (0-4) and the median FSS score was 4.4 (1-7). The PCFS and FSS were positively correlated (r = 0.49, p < 0.01; OR: 1.88, 95% CI: 1.68-2.10). Both functional status and fatigue were associated with quality of life, which was lower in older patients, those with higher BMI, those with systemic disease, those not exercising regularly, and those with more severe COVID-19 infection (defined by dyspnea, pneumonia as indicated by computed tomography, hospitalization, length of stay, ICU admission, intubation, and the need for home oxygen after discharge).

Conclusion: Fatigue may cause poorer functional status regardless of the time since COVID-19 diagnosis. In this study, patients with FSS scores of >4.78 showed moderate to severe functional limitations. It is important to address modifiable patient risk factors and reduce the severity of COVID-19 infection.

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COVID-19 感染后功能状态与疲劳之间的关系：来自土耳其的一项多中心研究。

背景/目的：COVID-19 的症状可能会持续数月。疲劳是 COVID-19 的持续症状之一，它会降低功能状态。疲劳、功能状态和其他各种因素之间的关系很少受到关注，本研究旨在解决这一问题：这项多中心横断面研究纳入了感染 COVID-19 的患者。年龄、性别、体重指数（BMI）、婚姻状况、吸烟状况、是否患有慢性疾病及病程长短、合并症指数、规律的运动习惯、确诊 COVID-19 后的时间、住院情况、住院时间、插管情况、出院后的家庭氧疗情况、是否参加肺康复计划、是否接受过肺康复治疗、是否参加过肺康复计划、是否参加过肺康复计划、是否参加过肺康复计划、是否参加过肺康复计划、是否参加过肺康复计划、是否参加过肺康复计划此外，还记录了患者是否参加肺康复计划、是否出现呼吸困难、是否咳嗽、是否有痰，以及医学研究委员会、COVID 后功能状态（PCFS）、疲劳严重程度量表（FSS）和 EQ-5D-5L 问卷评分。结果：我们共招募了 1095 名患者，包括 603 名男性（55%）和 492 名女性（45%），平均年龄为 50 ± 14 岁。最常见的慢性肺部疾病是慢性阻塞性肺病（11%），266 名患者（29%）患有非肺部疾病。COVID-19确诊后的中位时间为5个月；住院率为47%。PCFS 评分中位数为 1（0-4）分，FSS 评分中位数为 4.4（1-7）分。PCFS 和 FSS 呈正相关（r = 0.49，p < 0.01；OR：1.88，95% CI：1.68-2.10）。功能状态和疲劳都与生活质量有关，年龄较大、体重指数（BMI）较高、患有全身性疾病、不经常锻炼以及感染 COVID-19 较严重（定义为呼吸困难、计算机断层扫描显示的肺炎、住院、住院时间、入住 ICU、插管以及出院后需要家庭供氧）的患者的生活质量较低：结论：无论 COVID-19 诊断时间长短，疲劳都可能导致患者功能状态较差。在本研究中，FSS 评分大于 4.78 分的患者表现出中度到重度的功能限制。解决患者可改变的风险因素并降低 COVID-19 感染的严重程度非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.