Evaluation of volume measurements of neuroanatomical structures related to speech in multiple sclerosis patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-16 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5839

Hıdır Pekmez, Anıl Altiparmak, Feyza Inceoğlu, Mehmet Akçiçek, Aslı Bolayir, Zeynep Özbay, Merve Aydin, Muhammed Furkan Arpaci

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引用次数: 0

Abstract

Background/aim: Individuals with multiple sclerosis (MS) may experience various speech-related issues, including decreased speech rate, increased pauses, and changes in speech rhythms. The purpose of this study was to compare the volumes of speech-related neuroanatomical structures in MS patients with those in a control group.

Materials and methods: The research was conducted in the Neurology and Radiology Departments of Malatya Training and Research Hospital. The records of patients who presented to the Neurology Department between 2019 and 2022 were examined. The study included the magnetic resonance imaging (MRI) findings of 100 individuals, with 50 in the control group and 50 patients with MS, who had applied to the hospital in the specified years. VolBrain is a free system that works automatically over the internet (http://volbrain.upv.es/), enabling the measurement of brain volumes without human interaction. The acquired images were analyzed using the VolBrain program.

Results: As a result of our research, a significant decrease was found in the volume of 18 of 26 speech-related regions in MS patients. It was determined that whole brain volumes decreased in the MS group compared to the control group.

Conclusion: In our study, volume measurements of more speech-related areas were performed, unlike the few related studies previously conducted. We observed significant atrophy findings in the speech-related areas of the frontal, temporal, and parietal lobes of MS patients.

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评估多发性硬化症患者与语言有关的神经解剖结构的体积测量值。

背景/目的：多发性硬化症（MS）患者可能会出现各种与言语相关的问题，包括语速下降、停顿增加和言语节奏改变。本研究的目的是比较多发性硬化症患者与对照组的语言相关神经解剖结构的体积：研究在马拉蒂亚培训与研究医院神经内科和放射科进行。研究对象为 2019 年至 2022 年期间在神经内科就诊的患者。研究包括 100 人的磁共振成像（MRI）结果，其中对照组 50 人，多发性硬化症患者 50 人，他们都是在规定年份内到医院就诊的。VolBrain 是一个免费系统，可通过互联网（http://volbrain.upv.es/）自动运行，无需人工操作即可测量脑容量。获得的图像通过 VolBrain 程序进行分析：我们的研究结果表明，在多发性硬化症患者的 26 个语言相关区域中，有 18 个区域的体积明显缩小。与对照组相比，多发性硬化症患者的全脑体积也有所下降：在我们的研究中，对更多语言相关区域进行了体积测量，这与之前进行的少数相关研究不同。我们观察到多发性硬化症患者额叶、颞叶和顶叶的语言相关区域出现了明显的萎缩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.