Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5850

Eser Bulut, Ali Küpeli, Mehmet Akif Ramazanoğlu, Hasan Rıza Aydin, İbrahim Sibal, Fatih Biçaklioğlu, Fatih Yildirim, Şenol Adanur, Salih Al

{"title":"Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma.","authors":"Eser Bulut, Ali Küpeli, Mehmet Akif Ramazanoğlu, Hasan Rıza Aydin, İbrahim Sibal, Fatih Biçaklioğlu, Fatih Yildirim, Şenol Adanur, Salih Al","doi":"10.55730/1300-0144.5850","DOIUrl":null,"url":null,"abstract":"Background/aim: To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC).Materials and methods: Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups.Results: No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03.Conclusions: Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407362/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.55730/1300-0144.5850","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aim: To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC).

Materials and methods: Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups.

Results: No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03.

Conclusions: Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.

查看原文本刊更多论文

性别特异性腹部脂肪组织成分对透明细胞肾细胞癌 WHO/ISUP 核分级的影响

背景/目的：研究透明细胞肾细胞癌（ccRCC）中与性别相关的内脏肥胖与WHO/ISUP核分级之间的关系：在2018年1月至2022年6月期间，对95名接受腹部计算机断层扫描检查的病理证实的ccRCC患者（56名男性和39名女性）进行了回顾性研究。患者被分为两组：低WHO/ISUP核分级ccRCC和高WHO/ISUP核分级ccRCC（分别为58人和37人）。记录两组患者的身高、体重、体重指数（BMI）、性别、年龄、皮下脂肪面积（SFA）、内脏脂肪面积（VFA）、总脂肪面积（TFA）和内脏脂肪百分比（VF%）：结果：两组患者在年龄、体重指数（BMI）、内脏脂肪面积（SFA）或内脏脂肪百分比（TFA）方面无明显差异，但高级别患者组的内脏脂肪面积（VFA）和内脏脂肪百分比（VF%）明显高于高级别患者组。在男性中，肿瘤最大直径（MTD）（灵敏度为 67.8%，特异度为 76.9%）的曲线下面积（AUC）最高，而在女性中，VF%（灵敏度为 70.0%，特异度为 73.7%）的曲线下面积（AUC）最高。在女性高级别ccRCC患者中，VF%的几率比（OR）为1.09，而在男性中，MTD是ccRCC的独立预测因子，其几率比（OR）为1.03：与性别相关的体脂肪组织，包括VFA和VF%，可用于估计ccRCC患者的WHO/ISUP核分级，尤其是女性患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.