Distal interphalangeal joint involvement in patients with rheumatoid arthritis: Where are we?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-23 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5847

Mete Pekdiker, Sertaç Ketenci, Gökhan Sargin

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引用次数: 0

Abstract

Background/aim: Rheumatoid arthritis (RA) usually affects the wrist, metacarpophalangeal joint, and proximal interphalangeal joint of the hands. However, the distal interphalangeal (DIP) joints may also be involved in RA patients. In this study, we aimed to evaluate the frequency and associated factors of DIP joint erosion in patients with RA.

Materials and methods: Medical records of patients with RA were reviewed retrospectively. Patients with major trauma affecting DIP joints, osteoarthritis, erosive osteoarthritis, psoriatic arthritis, systemic sclerosis, calcium pyrophosphate dihydrate disease, and gout were excluded. Anteroposterior hand X-rays were evaluated and patients were divided into groups according to autoantibody profile.

Results: We reviewed 1213 patients with a mean age of 54.3 ± 12.5 years; 82.8% of them were female, and 95.4% had RA-type erosive changes. The DIP erosion rate was 12%. DIP involvement was generally unilateral and asymmetric, with the 3rd finger being the most commonly affected joint. Patients with DIP erosions had a significantly longer disease duration (p = 0.036). Older age was an independent predictive factor for DIP erosion (p = 0.001).

Conclusion: In this large-sample study, we reported DIP joint involvement in patients with RA. Advanced age could have affected the results because hand erosions increase above 50 years in a healthy population. Our results may provide a different perspective on joint involvement in RA.

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类风湿性关节炎患者的远端指间关节受累：进展如何？

背景/目的：类风湿性关节炎（RA）通常累及腕关节、掌指关节和近端指间关节。然而，RA 患者的远端指间关节（DIP）也可能受累。在这项研究中，我们旨在评估 RA 患者 DIP 关节侵蚀的频率和相关因素：回顾性审查 RA 患者的病历。排除了影响 DIP 关节的重大创伤、骨关节炎、侵蚀性骨关节炎、银屑病关节炎、系统性硬化症、焦磷酸钙二水合物疾病和痛风的患者。对手部前胸X光片进行评估，并根据自身抗体情况将患者分为几组：我们对 1213 名患者进行了复查，他们的平均年龄为（54.3 ± 12.5）岁；82.8% 的患者为女性，95.4% 的患者有 RA 型侵蚀性病变。DIP侵蚀率为12%。DIP受累一般为单侧且不对称，最常受影响的关节是三指。DIP侵蚀患者的病程明显较长（p = 0.036）。年龄较大是DIP侵蚀的一个独立预测因素（p = 0.001）：在这项大样本研究中，我们报告了RA患者DIP关节受累的情况。结论：在这项大样本研究中，我们报告了 RA 患者的 DIP 关节受累情况。高龄可能会影响研究结果，因为在健康人群中，50 岁以上的手部侵蚀会增加。我们的研究结果可能从另一个角度反映了 RA 患者的关节受累情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.