Serum Alpha-synuclein in Restless Legs Syndrome.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-09-16 DOI:10.1093/sleep/zsae217

Aboud Tahanis, Vera Hashem, William Ondo

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引用次数: 0

Abstract

Study objectives: To determine any correlation between serum alpha-synuclein (α-syn) concentrations and restless legs syndrome (RLS), and to explore the impact of intravenous iron supplementation on serum α-syn levels.

Methods: We collected clinical data on 113 RLS patients in whom serum α-syn levels were quantified using an ELISA kit and compared to a group of 45 age matched controls. A subset of 9 RLS patients who received intravenous (IV) iron underwent pre- and post-treatment blood sampling to assess α-syn and ferritin response.

Results: Family history of RLS was reported by 62.8% of patients, and current dopaminergic augmentation was observed in 31.0%. Low serum ferritin levels below 75 μg/L were seen in 39.8%. Serum α-syn levels were found to be significantly decreased in RLS patients (mean: 7.7 ng/ml) compared to controls (mean: 10.7 ng/ml,), p<0.05. Stratification based on sex, age and age of onset, did not reveal significant differences in α-syn levels. In 9 RLS patients who received IV iron treatment, a linear correlation between fold change in α-syn and ferritin was observed (R: 0.7, p <0.05). The temporal relation between serum α-syn and IV iron treatment showed a gradual decline of α-syn and ferritin by time correlation (p = 0.023, R: -0.739).

Conclusion: In our study of 113 RLS subjects, serum α-syn levels were decreased in RLS patients compared to healthy controls and increased in the 9 patients who received IV iron treatment in correlation with ferritin. This correlation could suggest a mechanism for reduced dopamine transmission in RLS.

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不宁腿综合征中的血清α-突触核蛋白

研究目的确定血清α-突触核蛋白（α-syn）浓度与不安腿综合征（RLS）之间的相关性，并探讨静脉补铁对血清α-syn水平的影响：我们收集了 113 名 RLS 患者的临床数据，使用 ELISA 试剂盒对这些患者的血清 α-syn 水平进行了量化，并与 45 名年龄匹配的对照组进行了比较。9名接受静脉注射（IV）铁剂的RLS患者接受了治疗前后的血液采样，以评估α-syn和铁蛋白的反应：结果：62.8%的患者有 RLS 家族史，31.0%的患者有多巴胺能增强症状。39.8%的患者血清铁蛋白水平低于75微克/升。与对照组（平均：10.7 纳克/毫升）相比，RLS 患者的血清 α-syn 水平明显下降（平均：7.7 纳克/毫升）：在我们对 113 名 RLS 受试者进行的研究中，与健康对照组相比，RLS 患者的血清 α-syn 水平有所下降，而在接受静脉注射铁剂治疗的 9 名患者中，α-syn 水平与铁蛋白相关性有所增加。这种相关性可能暗示了 RLS 中多巴胺传递减少的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.