Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence.

IF 2 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.13906

ZhiRong Liu, YuanYing Wang, ShiHao Wang, JiaXin Wu, Cui Jia, Xuan Tan, XinLian Liu, XinWei Huang, LuShun Zhang

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引用次数: 0

Abstract

Background: The genetic association between urticaria and mental disorders and whether inflammatory cytokines mediate this process remains unclear.

Materials and methods: A Mendelian randomization (MR) approaches to elucidate the causal relationship between urticaria and mental disorders and to validate the mediation of inflammatory cytokines. Genome-wide association study (GWAS) databases used were obtained from Psychiatric Genomics Cooperation (PGC), GWAS Catalog, and FinnGen Consortium. Our study was conducted using inverse variance weighted (IVW) and Bayesian weighted MR (BWMR) methods for joint analysis.

Results: The MR results showed that urticaria increased the risk of attention deficit hyperactivity disorder (ADHD) (odds ratio [OR] $=$ 1.088, 95% confidence interval [CI]: 1.026-1.154, p $=$ 0.0051); cholinergic urticaria increased the risk of bipolar disorder (BD) (OR $=$ 1.012, 95% CI: 1.001-1.022, p $=$ 0.0274); dermatographic urticaria increased the risk of ADHD (OR $=$ 1.057, 95% CI: 1.005-1.112, p $=$ 0.0323); idiopathic urticaria increased the risk of schizophrenia (SCZ) (OR $=$ 1.057, 95% CI: 1.005-1.112, p $=$ 0.0323); other unspecified urticaria increased the risk of ADHD (OR $=$ 1.085, 95% CI: 1.023-1.151, p $=$ 0.0063). We found that eight inflammatory cytokines were negatively associated with mental disorders and seven inflammatory cytokines were positively associated with mental disorders. Finally, our results suggested that inflammatory cytokines do not act as mediators between urticaria and mental disorders.

Conclusions: Our study reveals a causal relationship between urticaria and the increased risk of mental disorders. We suggest that the treatment of urticaria could incorporate psychiatric interventions and mental health assessment of patients.

查看原文本刊更多论文

揭示荨麻疹、炎症细胞因子和精神障碍之间的因果关系：遗传证据的视角。

背景：荨麻疹与精神障碍之间的遗传关联以及炎性细胞因子是否介导了这一过程仍不清楚：采用孟德尔随机化（MR）方法阐明荨麻疹与精神障碍之间的因果关系，并验证炎性细胞因子的中介作用。所使用的全基因组关联研究（GWAS）数据库来自精神病基因组学合作组织（PGC）、GWAS Catalog和FinnGen Consortium。我们的研究采用逆方差加权（IVW）和贝叶斯加权磁共振（BWMR）方法进行联合分析：MR结果显示，荨麻疹增加了注意力缺陷多动障碍（ADHD）的风险（几率比[OR] = $ = $ 1.088，95%置信区间[CI]：1.026-1.154）：1.026-1.154，p = $ = $ 0.0051）；胆碱能性荨麻疹增加了双相情感障碍（BD）的风险（OR = $ = $ 1.012，95% CI：1.001-1.022，p = $ = $ 0.0274）；皮肤荨麻疹增加了多动症的风险（OR = $ = $ 1.057，95% CI：1.005-1.112，p = $ = $ 0.0323）；特发性荨麻疹增加了精神分裂症（SCZ）的风险（OR = $ = $ 1.057，95% CI：1.005-1.112，p = $ = $ 0.0323）；其他不明原因的荨麻疹增加了多动症的风险（OR = $ = $ 1.085，95% CI：1.023-1.151，p = $ = $ 0.0063）。我们发现，8 种炎症细胞因子与精神障碍呈负相关，7 种炎症细胞因子与精神障碍呈正相关。最后，我们的研究结果表明，炎性细胞因子并不是荨麻疹和精神障碍之间的中介因子：我们的研究揭示了荨麻疹与精神障碍风险增加之间的因果关系。我们建议，在治疗荨麻疹的过程中，可以对患者进行精神干预和心理健康评估。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.