High seroprevalence of IgM antibodies against chikungunya among patients with acute febrile illness seeking healthcare in a malaria-endemic area in the Afar Region, Northeast Ethiopia.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.1177/20503121241276557
Biruk Zerfu, Tesfu Kassa, Gezahegne Mamo, James W Larrick, Mengistu Legesse
{"title":"High seroprevalence of IgM antibodies against chikungunya among patients with acute febrile illness seeking healthcare in a malaria-endemic area in the Afar Region, Northeast Ethiopia.","authors":"Biruk Zerfu, Tesfu Kassa, Gezahegne Mamo, James W Larrick, Mengistu Legesse","doi":"10.1177/20503121241276557","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Chikungunya is a disease caused by <i>Aedes</i> mosquito-borne chikungunya virus infection. This disease is becoming one of the emerging/re-emerging viral diseases in tropical and subtropical countries but is neglected by public health systems. This study assessed the seroprevalence of chikungunya virus infection among patients with acute febrile illness seeking healthcare in a malaria-endemic area in the Afar Region, Northeast Ethiopia.</p><p><strong>Methods: </strong>An institution-based cross-sectional study was employed from September 2022 to March 2023 to assess the seroprevalence of chikungunya virus infection among malaria-suspected febrile patients attending health institutes in the Afar Region. Sociodemographic, clinical features, and venous blood were collected from each study participant. Blood films were prepared and examined for plasmodium infection using microscopy. Sera were separated and screened for anti-chikungunya virus IgM and IgG antibodies using an enzyme-linked immunosorbent assay. Data were entered into Epi Data 3.1 and analyzed using Stata/SE 14.2.</p><p><strong>Results: </strong>In this study, 368 malaria-suspected febrile patients (55.4% female, aged 5-80 years old, mean ± SD = 27.28 ± 14.0) participated. The prevalence of anti-chikungunya virus IgM antibodies, indicating acute infection, was 47.8%, while the prevalence of IgG antibodies, indicating previous exposure, was 6.3%. Nonmarried participants were found to be more likely to have acute chikungunya virus infection (AOR = 2.34, 95% CI: 1.141-4.964), and back pain was associated with higher likelihood of acute infection (AOR = 1.785; 95% CI: 1.078-2.954). About 10.6% of the participants tested positive for <i>Plasmodium</i> parasite infection, with <i>P. falciparum</i> (84.6%) being the most common, followed by <i>P. vivax</i> (10.3%) and mixed (5.1%) infections.</p><p><strong>Conclusion: </strong>The study revealed a high seroprevalence of acute chikungunya virus infection among febrile patients in the Afar Region, highlighting the importance of regular screening for arbovirus infection in febrile patients to control and mitigate chikungunya spread.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241276557"},"PeriodicalIF":2.3000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388298/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAGE Open Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20503121241276557","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Chikungunya is a disease caused by Aedes mosquito-borne chikungunya virus infection. This disease is becoming one of the emerging/re-emerging viral diseases in tropical and subtropical countries but is neglected by public health systems. This study assessed the seroprevalence of chikungunya virus infection among patients with acute febrile illness seeking healthcare in a malaria-endemic area in the Afar Region, Northeast Ethiopia.

Methods: An institution-based cross-sectional study was employed from September 2022 to March 2023 to assess the seroprevalence of chikungunya virus infection among malaria-suspected febrile patients attending health institutes in the Afar Region. Sociodemographic, clinical features, and venous blood were collected from each study participant. Blood films were prepared and examined for plasmodium infection using microscopy. Sera were separated and screened for anti-chikungunya virus IgM and IgG antibodies using an enzyme-linked immunosorbent assay. Data were entered into Epi Data 3.1 and analyzed using Stata/SE 14.2.

Results: In this study, 368 malaria-suspected febrile patients (55.4% female, aged 5-80 years old, mean ± SD = 27.28 ± 14.0) participated. The prevalence of anti-chikungunya virus IgM antibodies, indicating acute infection, was 47.8%, while the prevalence of IgG antibodies, indicating previous exposure, was 6.3%. Nonmarried participants were found to be more likely to have acute chikungunya virus infection (AOR = 2.34, 95% CI: 1.141-4.964), and back pain was associated with higher likelihood of acute infection (AOR = 1.785; 95% CI: 1.078-2.954). About 10.6% of the participants tested positive for Plasmodium parasite infection, with P. falciparum (84.6%) being the most common, followed by P. vivax (10.3%) and mixed (5.1%) infections.

Conclusion: The study revealed a high seroprevalence of acute chikungunya virus infection among febrile patients in the Afar Region, highlighting the importance of regular screening for arbovirus infection in febrile patients to control and mitigate chikungunya spread.

在埃塞俄比亚东北部阿法尔地区疟疾流行区就医的急性发热性疾病患者中,基孔肯雅病毒 IgM 抗体血清阳性率较高。
目的:基孔肯雅病是由伊蚊传播的基孔肯雅病毒感染引起的疾病。这种疾病正在成为热带和亚热带国家新发/再发的病毒性疾病之一,但却被公共卫生系统所忽视。本研究评估了在埃塞俄比亚东北部阿法尔地区疟疾流行区就医的急性发热性疾病患者中基孔肯雅病毒感染的血清流行率:在 2022 年 9 月至 2023 年 3 月期间开展了一项以医疗机构为基础的横断面研究,以评估在阿法尔地区医疗机构就诊的疟疾疑似发热病人中基孔肯雅病毒感染的血清流行率。研究人员收集了每位参与者的社会人口学特征、临床特征和静脉血。制备血片,用显微镜检查疟原虫感染情况。分离血清,用酶联免疫吸附试验检测抗基孔肯雅病毒 IgM 和 IgG 抗体。数据输入 Epi Data 3.1,并使用 Stata/SE 14.2 进行分析:本研究共有 368 名疑似疟疾发热患者(55.4% 为女性,年龄在 5-80 岁之间,平均值 ± SD = 27.28 ± 14.0)参加。抗基孔肯雅病毒 IgM 抗体的流行率为 47.8%,表示急性感染,而 IgG 抗体的流行率为 6.3%,表示以前接触过。研究发现,未婚参与者更有可能急性感染基孔肯雅病毒(AOR = 2.34,95% CI:1.141-4.964),背痛与急性感染的可能性较高(AOR = 1.785;95% CI:1.078-2.954)。约 10.6% 的参与者疟原虫感染检测呈阳性,其中最常见的是恶性疟原虫(84.6%),其次是间日疟原虫(10.3%)和混合感染(5.1%):研究显示,阿法尔地区发热病人中急性基孔肯雅病毒感染的血清流行率很高,这凸显了在发热病人中定期筛查虫媒病毒感染以控制和减少基孔肯雅病毒传播的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信