Strategies to improve autoimmune neurological diseases treatment

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2024-11-01 DOI:10.1016/j.neurol.2024.08.005

F. Leypoldt

引用次数: 0

Abstract

There is a need to improve therapies in autoimmune neurologic conditions. Yet which strategic objectives are required, what are the barriers that stand before reaching them, and what are the options to address them? This article tries to summarize these objectives and their respective barriers. It discusses the difficulties in identifying molecular targets, biomarker-defined subgroups, the merits of upstream and downstream-targeted therapies, the need to develop autoreactivity-specific treatments in contrast to cell-type specific therapies, and the “evidence-bottleneck”. Its focus is on autoantigen-specific autoimmunopathies in neurology. It also discusses the role of B- and T-cells in autoimmune neurology and how these can be exploited therapeutically. Finally, it argues for improved training of present and future neuroimmunologists.

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改善自身免疫性神经疾病治疗的策略。

需要改进自身免疫性神经疾病的疗法。然而，需要实现哪些战略目标，在实现这些目标之前存在哪些障碍，又有哪些方案可以解决这些问题？本文试图总结这些目标及其各自的障碍。文章讨论了确定分子靶点的困难、生物标志物定义的亚组、上游和下游靶向疗法的优点、开发自身活性特异性疗法而非细胞类型特异性疗法的必要性以及 "证据瓶颈"。报告的重点是神经病学中的自身抗原特异性自身免疫病。报告还讨论了 B 细胞和 T 细胞在自身免疫性神经病学中的作用，以及如何利用这些细胞进行治疗。最后，该书主张加强对现在和未来神经免疫学家的培训。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.