The pink side of spondyloarthritis: a narrative review across pathogenesis and clinical manifestations in women.

IF 1.2 Q4 RHEUMATOLOGY
C Rizzo, L La Barbera, A D'Antonio, F Camarda, P Conigliaro, M S Chimenti, G Guggino
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引用次数: 0

Abstract

Objective: The aim of the present review was to highlight gender and sex differences in spondyloarthritis (SpA) to achieve a better awareness of the unmet needs of women with SpA.

Methods: A literature search of PubMed was performed, including manuscripts in English published in the last twenty years, to select and analyze articles related to SpA and sex and gender differences in epidemiology, genetics, immunology, clinical features, and response to treatment.

Results: Women and men with SpA have different disease phenotypes, and this heterogeneity mirrors anatomical, physiological, and hormonal differences, as well as peculiar variability in response to treatment. These underestimated differences, which include several biological factors and intertwined social factors, contribute to diagnostic delay and increased disease burden in women with SpA.

Conclusions: This review elucidates gender differences in SpA and raises awareness about the need for gender-related stratification of SpA patients with the concomitant implementation of SpA gender differences in future research and upcoming clinical trials. A deeper knowledge of SpA in women is indispensable to pave the way for real personalized medicine for SpA patients to reduce misdiagnosis and delay in intercepting the disease.

脊柱关节炎的粉色一面:女性发病机制和临床表现的叙述性综述。
目的:本综述旨在强调脊柱关节炎(SpA)的性别差异:本综述旨在强调脊柱关节炎(Spondyloarthritis,SpA)的性别差异,以便更好地了解女性脊柱关节炎患者尚未得到满足的需求:方法:在PubMed上进行文献检索,包括过去20年中发表的英文稿件,选择并分析与SpA以及在流行病学、遗传学、免疫学、临床特征和对治疗的反应等方面的性别差异相关的文章:结果:患有 SpA 的女性和男性具有不同的疾病表型,这种异质性反映了解剖学、生理学和荷尔蒙的差异,以及对治疗反应的特殊差异性。这些被低估的差异包括多种生物因素和相互交织的社会因素,它们导致了SpA女性患者的诊断延迟和疾病负担加重:本综述阐明了SpA的性别差异,并提高了人们对SpA患者性别分层必要性的认识,同时在未来的研究和即将开展的临床试验中考虑到了SpA的性别差异。对女性SpA的深入了解是必不可少的,这将为SpA患者真正的个性化医疗铺平道路,从而减少误诊和延误病情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reumatismo
Reumatismo RHEUMATOLOGY-
CiteScore
2.10
自引率
7.10%
发文量
20
审稿时长
10 weeks
期刊介绍: Reumatismo is the official Journal of the Italian Society of Rheumatology (SIR). It publishes Abstracts and Proceedings of Italian Congresses and original papers concerning rheumatology. Reumatismo is published quarterly and is sent free of charge to the Members of the SIR who regularly pay the annual fee. Those who are not Members of the SIR as well as Corporations and Institutions may also subscribe to the Journal.
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