Molecular Characteristics and Expression of TKTL1 in Germ Cells: Implications for Nontumour Cell Research.

IF 1.6 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Reproduction in Domestic Animals Pub Date : 2024-09-01 DOI:10.1111/rda.14723

Xiaole Yuan, Huaiyan Kang, Bo Liu, Xiuwei Yu, Haijing Zhu, Shenghui Chen, Xiaomin Du

引用次数: 0

Abstract

TKTL1 is a crucial regulatory enzyme in the pentose phosphate pathway (PPP) and plays a significant role in energy synthesis. It is expressed in various tumour tissues, with its expression level closely associated with tumour invasion, metastasis and prognosis. Recent studies utilising proteomic analysis and other methods have highlighted the noteworthy expression of the TKTL1 gene in germ cells, particularly in spermatogonia and ovarian cells. Consequently, this article reviews the molecular characteristics of TKTL1 and its expression in germ cells to provide a reference for research on TKTL1 beyond tumour cells.

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TKTL1 在生殖细胞中的分子特征和表达：对非肿瘤细胞研究的意义

TKTL1 是磷酸戊糖途径（PPP）中的一个重要调节酶，在能量合成中发挥着重要作用。它在各种肿瘤组织中均有表达，其表达水平与肿瘤的侵袭、转移和预后密切相关。最近利用蛋白质组分析和其他方法进行的研究强调了 TKTL1 基因在生殖细胞中的显著表达，尤其是在精原细胞和卵巢细胞中。因此，本文回顾了TKTL1的分子特征及其在生殖细胞中的表达，为肿瘤细胞以外的TKTL1研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproduction in Domestic Animals 农林科学-奶制品与动物科学

CiteScore

3.00

自引率

5.90%

发文量

238

审稿时长

4-8 weeks

期刊介绍： The journal offers comprehensive information concerning physiology, pathology, and biotechnology of reproduction. Topical results are currently published in original papers, reviews, and short communications with particular attention to investigations on practicable techniques. Carefully selected reports, e. g. on embryo transfer and associated biotechnologies, gene transfer, and spermatology provide a link between basic research and clinical application. The journal applies to breeders, veterinarians, and biologists, and is also of interest in human medicine. Interdisciplinary cooperation is documented in the proceedings of the joint annual meetings. Fields of interest: Animal reproduction and biotechnology with special regard to investigations on applied and clinical research.