Safety of Intrauterine Transfusion Performed Beyond 34 weeks of Gestation.

IF 2.7 2区医学 Q2 GENETICS & HEREDITY

Prenatal Diagnosis Pub Date : 2024-09-20 DOI:10.1002/pd.6670

Ariane C Youssefzadeh, Jinnen Masri, Lisa M Korst, Arlyn Llanes, Catherine Hamzeh, Ramen H Chmait

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引用次数: 0

Abstract

Objective: To describe (1) procedure-related complications, and (2) gestational age (GA) at delivery in patients who received their final intrauterine transfusion (IUT) at ≥ 34 weeks 0 days versus at < 34 weeks 0 days.

Methods: This was a retrospective study of pregnancies treated with IUT. Procedure-related complications were defined as any of the following within 48 h of IUT: (1) rupture of membranes or preterm delivery, (2) intrauterine infection, (3) fetal death, (4) fetal compromise resulting in emergency cesarean, or (5) neonatal death. Patient and procedural characteristics were described among patients with final IUT at ≥ 34 weeks 0 days and at < 34 weeks 0 days.

Results: We studied 94 pregnancies with 237 IUTs; 35 (37.2%) had their last IUT at ≥ 34 weeks 0 days and 59 (62.8%) had their last IUT at < 34 weeks 0 days. Three procedure-related complications occurred (1.3% of procedures, 3.2% of pregnancies). All resulted in emergency cesarean section; 1 case performed at < 34 weeks 0 days resulted in neonatal death. The remaining 2 occurred during IUT at ≥ 34 weeks 0 days. Pregnancies with the last IUT at ≥ 34 weeks 0 days delivered at a median GA of 37.1 weeks.

Conclusions: Complications were rare. IUT performed at ≥ 34 weeks 0 days appeared safe.

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妊娠超过 34 周进行宫内输血的安全性。

目的描述(1)与手术相关的并发症，以及(2)最后一次宫内输液（IUT）时间≥34周0天与<34周0天的患者分娩时的胎龄（GA）：这是一项对接受宫内输液治疗的孕妇进行的回顾性研究。与手术相关的并发症是指在 IUT 48 小时内发生以下任何一种情况：(1) 胎膜破裂或早产；(2) 宫内感染；(3) 胎儿死亡；(4) 胎儿受损导致紧急剖宫产；或 (5) 新生儿死亡。结果：我们研究了94例妊娠中的237例宫内感染患者：我们对94例妊娠的237例IUT进行了研究，其中35例（37.2%）的最后一次IUT时间≥34周0天，59例（62.8%）的最后一次IUT时间<34周0天。发生了 3 起与手术相关的并发症（占手术的 1.3%，占妊娠的 3.2%）。所有并发症都导致了紧急剖宫产；1 例在妊娠小于 34 周 0 天时进行的手术导致新生儿死亡。其余 2 例发生在≥34 周 0 天的 IUT 期间。最后一次IUT时间≥34周0天的孕妇的中位孕期为37.1周：并发症罕见。在≥34周0天时进行IUT似乎是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prenatal Diagnosis 医学-妇产科学

CiteScore

5.80

自引率

13.30%

发文量

204

审稿时长

2 months

期刊介绍： Prenatal Diagnosis welcomes submissions in all aspects of prenatal diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing: all aspects of fetal imaging, including sonography and magnetic resonance imaging; prenatal cytogenetics, including molecular studies and array CGH; prenatal screening studies; fetal cells and cell-free nucleic acids in maternal blood and other fluids; preimplantation genetic diagnosis (PGD); prenatal diagnosis of single gene disorders, including metabolic disorders; fetal therapy; fetal and placental development and pathology; development and evaluation of laboratory services for prenatal diagnosis; psychosocial, legal, ethical and economic aspects of prenatal diagnosis; prenatal genetic counseling