ST-Segment Alterations in the Electrocardiogram of Acute Pulmonary Thromboembolism: A Rabbit Model.

IF 1.9 4区 医学 Q3 PHYSIOLOGY
Physiological research Pub Date : 2024-08-31
D Liu, B Duan, M Zhao, L Wu, Y Cao, N Liu, Z Xue, Z He, J Mi
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Abstract

In this study, we investigated the mechanism underlying electrocardiogram (ECG) alterations in a rabbit model of acute pulmonary thromboembolism (PTE). Twelve healthy adult New Zealand white rabbits were used, with eight in the experimental group (PTE group) and four in the control group. After developing the rabbit model of acute PTE, ECG and coronary angiography were performed. HE staining was conducted on the right and left ventricular tissues, and polymerase chain reaction (PCR) was used to determine brain natriuretic peptide (BNP), tumor necrosis factor-alpha (TNF-?), and Troponin I (TNI) mRNA expression in the myocardium. There were considerable changes in the ST segment of the ECG in the PTE group. Coronary angiography revealed the absence of spasm, stenosis, and occlusion. In the plasma of the PTE group, the levels of D-dimer, BNP, TNF-?, and TNI were significantly elevated, and these changes were statistically significant (P<0.05). PCR analysis of ventricular myocardial tissue indicated significantly higher levels of BNP, TNF-?, and TNI mRNA in the PTE group than in the control group. These differences were statistically significant (P<0.05). The ST-T variations on the ECG of rabbits with acute PTE correlate strongly with the temporary changes in right heart volume caused by acute PTE. Keywords: Animal model of pulmonary embolism, B-type natriuretic peptide, Electrocardiogram, Pulmonary thromboembolism, Troponin I, Tumor necrosis factor-alpha.

急性肺血栓栓塞症心电图的 ST 段改变:兔子模型
本研究探讨了急性肺血栓栓塞症(PTE)兔模型心电图(ECG)改变的机制。我们使用了 12 只健康的成年新西兰白兔,其中 8 只为实验组(PTE 组),4 只为对照组。建立急性 PTE 兔模型后,进行心电图和冠状动脉造影。对左右心室组织进行 HE 染色,并用聚合酶链反应(PCR)测定心肌中脑钠肽(BNP)、肿瘤坏死因子-α(TNF-?)和肌钙蛋白 I(TNI)mRNA 的表达。PTE 组心电图的 ST 段有显著变化。冠状动脉造影显示没有痉挛、狭窄和闭塞。PTE 组血浆中的 D-二聚体、BNP、TNF-? 和 TNI 水平显著升高,这些变化具有统计学意义(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physiological research
Physiological research 医学-生理学
CiteScore
4.00
自引率
4.80%
发文量
108
审稿时长
3 months
期刊介绍: Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.
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