A comprehensive update on the potential of curcumin to enhance chemosensitivity in colorectal cancer.

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmacological Reports Pub Date : 2024-09-20 DOI:10.1007/s43440-024-00652-y

Mahdi Shadnoush, Mehrnaz Momenan, Veronique Seidel, Sascha Tierling, Nayeralsadat Fatemi, Ehsan Nazemalhosseini-Mojarad, Mohammad Tayefeh Norooz, Makan Cheraghpour

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Abstract

Colorectal cancer (CRC) is one of the most common cancers and a major cause of cancer-related mortality worldwide. The efficacy of chemotherapy agents in CRC treatment is often limited due to toxic side effects, heterogeneity of cancer cells, and the possibility of chemoresistance which promotes cancer cell survival through several mechanisms. Combining chemotherapy agents with natural compounds like curcumin, a polyphenol compound from the Curcuma longa plant, has been reported to overcome chemoresistance and increase the sensitivity of cancer cells to chemotherapeutics. Curcumin, alone or in combination with chemotherapy agents, has been demonstrated to prevent chemoresistance by modulating various signaling pathways, reducing the expression of drug resistance-related genes. The purpose of this article is to provide a comprehensive update on studies that have investigated the ability of curcumin to enhance the efficacy of chemotherapy agents used in CRC. It is hoped that it can serve as a template for future research on the efficacy of curcumin, or other natural compounds, combined with chemotherapy agents to maximize the effectiveness of therapy and reduce the side effects that occur in CRC or other cancers.

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全面更新姜黄素增强结直肠癌化疗敏感性的潜力。

结直肠癌（CRC）是全球最常见的癌症之一，也是导致癌症相关死亡的主要原因。由于毒副作用、癌细胞的异质性以及通过多种机制促进癌细胞存活的化疗抗药性的可能性，化疗药物在 CRC 治疗中的疗效往往受到限制。据报道，将化疗药物与姜黄素等天然化合物（姜黄素是一种来自姜黄属植物的多酚化合物）结合使用，可以克服化疗耐药性，提高癌细胞对化疗药物的敏感性。姜黄素单独使用或与化疗药物联合使用时，可通过调节各种信号通路，减少耐药性相关基因的表达，从而防止化疗产生耐药性。本文旨在全面介绍姜黄素增强用于治疗 CRC 的化疗药物疗效的最新研究进展。希望这篇文章能成为今后研究姜黄素或其他天然化合物与化疗药物结合的疗效的模板，以最大限度地提高治疗效果，减少 CRC 或其他癌症的副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological Reports 医学-药学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.