Long-chain polyunsaturated fatty acids supplementation and sepsis: a systematic review and meta-analysis.

IF 3.1 3区医学 Q1 PEDIATRICS

Pediatric Research Pub Date : 2024-09-19 DOI:10.1038/s41390-024-03579-5

Ariadna Witte Castro, María L Couce, Carmela de Lamas, Mª Rosario López-Giménez, Miguel Ángel Jiménez Varas, C Zozaya, Miguel Saenz de Pipaon

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引用次数: 0

Abstract

Background: Long chain polyunsaturated fatty acids (LCPUFAs) have proven to be essential for development in preterm infants and have been studied for their capacity to reduce inflammation and infection rates, including sepsis in enteral and parenteral nutrition. The aim of this review and meta-analysis is to gather the information available on this subject to determine if n-3 polyunsaturated fatty acids can reduce sepsis incidence in preterm infants.

Methods: This systematic review was conducted by searching in the databases MEDLINE (via PubMed), ISI-Web of Science, EMBASE, SCOPUS, SciELO, and Cochrane Library databases. We analyzed the data regarding sepsis using the Grading of Recommendations Assessment, Development and Evaluation approach to assess the quality of the evidence.

Results: A total of 40 trials were included for review and 35 trials had the data available for quantitative analysis. LCPUFAs supplementation did not reduce incidence of sepsis (relative risk (RR), confidence interval (CI) 0.95 [0.87, 1.03] P = 0.87; I² = 0%). These results remained consistent after the sensitivity analysis.

Conclusion: The results of this systematic review and meta-analysis indicate that LCPUFA supplementation is not associated with a significant decrease in the incidence of sepsis in premature infants.

Impact: Reviewing the information available about LCPUFA supplementation and sepsis since the results in previous Clinical Trials (CT) are inconclusive. It summarizes the results of 42 CT and we have not found conclusive results regarding sepsis in the literature. It could be of clinical interest for pediatricians and nutritionists.

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长链多不饱和脂肪酸补充剂与败血症：系统综述和荟萃分析。

背景：长链多不饱和脂肪酸（LCPUFAs）已被证明是早产儿发育所必需的物质，并已被研究用于降低炎症和感染率，包括肠内和肠外营养中的败血症。本综述和荟萃分析旨在收集这方面的信息，以确定 n-3 多不饱和脂肪酸是否能降低早产儿败血症的发病率：本系统综述通过在 MEDLINE（通过 PubMed）、ISI-Web of Science、EMBASE、SCOPUS、SciELO 和 Cochrane Library 数据库中进行检索。我们采用 "建议分级评估、发展和评价 "方法对有关败血症的数据进行了分析，以评估证据的质量：共有 40 项试验被纳入审查范围，其中 35 项试验的数据可用于定量分析。补充 LCPUFAs 并未降低败血症的发病率（相对风险 (RR)，置信区间 (CI) 0.95 [0.87, 1.03] P = 0.87；I2 = 0%）。这些结果在敏感性分析后保持一致：本系统综述和荟萃分析的结果表明，补充 LCPUFA 与早产儿败血症发病率的显著降低无关：由于之前的临床试验（CT）结果尚无定论，本研究回顾了有关补充 LCPUFA 和败血症的现有信息。该报告总结了 42 项临床试验的结果，我们在文献中未发现有关败血症的结论性结果。儿科医生和营养学家在临床上可能会对此感兴趣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Research 医学-小儿科

CiteScore

6.80

自引率

5.60%

发文量

473

审稿时长

3-8 weeks

期刊介绍： Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of children''s diseases and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies