The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral health & preventive dentistry Pub Date : 2024-09-12 DOI:10.3290/j.ohpd.b5740317

Xinchun Jiang, Mingkai Lin, Ping Xiao, Zhiyan Zhou, Yanli Zhang, Wenjuan Yan

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Abstract

Dental caries, one of the most prevalent diseases globally, affects individuals throughout their lifetimes. Recently, researchers have increasingly focused on postbiotics for caries prevention. Postbiotics, comprising inanimate microorganisms and/or their components, confer health benefits to the host. Growing evidence suggests postbiotics' potential anticaries effects. Specifically, numerous postbiotics have demonstrated the ability to inhibit dental caries onset and progression by modulating oral flora microecology and reducing human caries susceptibility. This review elaborates on the current research regarding postbiotics' anticaries effects, highlights some studies' shortcomings, and innovatively proposes that postbiotics could potentially influence tooth development and salivary characteristics through epigenetic modifications. Furthermore, it anticipates postbiotics' future application in personalised caries treatment, given their multifaceted anticaries potential.

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益生菌在龋齿预防和管理中的作用机制和应用价值。

龋齿是全球最普遍的疾病之一，影响人的一生。最近，研究人员越来越关注用于预防龋齿的益生元。益生元由无生命的微生物和/或其成分组成，可为宿主带来健康益处。越来越多的证据表明，益生元具有潜在的抗龋作用。具体而言，许多益生元已证明能够通过调节口腔菌群微生态和降低人类对龋齿的易感性来抑制龋齿的发生和发展。本综述阐述了目前有关益生菌后抗龋作用的研究，强调了一些研究的不足之处，并创新性地提出益生菌后有可能通过表观遗传修饰影响牙齿发育和唾液特征。此外，鉴于益生菌具有多方面的抗龋潜力，该研究还预测了益生菌未来在个性化龋病治疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.