Hallmarks of diabetes mellitus and insights into the therapeutic potential of synergy-based combinations of phytochemicals in reducing oxidative stress-induced diabetic complications.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-09-18 DOI:10.1080/14786419.2024.2402461

Mohammad Irfan Dar, Anu Gulya, Sageer Abass, Kapil Dev, Rabea Parveen, Sayeed Ahmad, Mohammad Irfan Qureshi

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Abstract

Diabetes mellitus (DM) is a serious health issue and is still one of the major causes of mortality around the globe. Natural products have progressively integrated into modern, advanced medical practices. Phytoconstituents from some medicinal plants have demonstrated therapeutic activity in treating different metabolic disorders and have been used to treat DM and its severe complications. The present review provides details of the major anti-diabetic targets identified in the literature and also provides comprehensive information regarding the therapeutic role of a synergy-based combination of phytoconstituents that functions by controlling specific molecular pathways synchronously by inhibiting certain key regulators involved in the development and progression of DM. The review also implicated the role of oxidative stress in diabetic complications and presented scientific validations of phytochemicals and their synergy-based combination using in vitro and or in vivo approaches.

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糖尿病的特征以及基于协同作用的植物化学物组合在减少氧化应激引起的糖尿病并发症方面的治疗潜力。

糖尿病（DM）是一个严重的健康问题，目前仍是全球死亡的主要原因之一。天然产品已逐步融入现代先进的医疗实践。一些药用植物中的植物成分在治疗不同的代谢紊乱方面显示出了治疗活性，并被用于治疗糖尿病及其严重并发症。本综述详细介绍了文献中确定的主要抗糖尿病靶点，还提供了有关植物成分协同组合治疗作用的全面信息，这种植物成分协同组合通过同步控制特定的分子通路，抑制参与 DM 发生和发展的某些关键调节因子而发挥作用。综述还指出了氧化应激在糖尿病并发症中的作用，并利用体外和体内方法对植物化学物质及其协同组合进行了科学验证。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.