Unlocking the health benefits of melatonin supplementation: A promising preventative and therapeutic strategy.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2024-09-20 DOI:10.1097/MD.0000000000039657

Firas S Azzeh, Waad W Kamfar, Mazen M Ghaith, Radi T Alsafi, Ghalia Shamlan, Mai A Ghabashi, Wesam F Farrash, Reema A Alyamani, Awfa Y Alazzeh, Sarah O Alkholy, El-Sayed H Bakr, Alaa H Qadhi, Ahmad F Arbaeen

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引用次数: 0

Abstract

Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. This review discusses MLT's potential preventative and therapeutic effects on various diseases. Several studies have focused on examining the molecular mechanisms through which MLT brings about its protective or therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases. Numerous preventative and therapeutic applications of MLT have been proposed, resulting from its ability to function as an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent. There is a need for further research to determine MLT's long-term effects on antioxidant defense systems, its preventative and therapeutic benefits, and its molecular basis.

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揭示补充褪黑激素对健康的益处：一种前景广阔的预防和治疗策略。

褪黑素（MLT）对控制人类的睡眠-觉醒模式至关重要。褪黑素在调节昼夜节律方面的作用早已得到认可，而它在治疗各种疾病方面的功效最近也得到了广泛关注。本综述将讨论 MLT 对各种疾病的潜在预防和治疗作用。一些研究重点探讨了 MLT 对各种疾病（包括癌症、肥胖症、冠状病毒和心血管疾病）产生保护或治疗作用的分子机制。由于 MLT 具有抗氧化、抗癌、抗炎和免疫调节的作用，因此提出了许多预防和治疗 MLT 的应用。需要进一步研究确定 MLT 对抗氧化防御系统的长期影响、其预防和治疗功效及其分子基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.