Factors Associated with Corticosteroid Adherence in Sarcoidosis.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM
Lung Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI:10.1007/s00408-024-00746-7
Marc A Judson, Wende Ouedraogo Ouedraogo, Kenneth M Fish, Robert DeLuca, Rachel VanCavage, Krishnaveni Sirigaddi, Recai Yucel
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引用次数: 0

Abstract

Purpose: We measured corticosteroid medication adherence (CMA) in sarcoidosis patients and analyzed if demographic and clinical factors, beliefs about medications, corticosteroid side-effects, psychosocial status, and the doctor-patient relationship were associated with corticosteroid adherence.

Methods: Sarcoidosis patients receiving corticosteroids were eligible to participate. CMA was measured using the Medication Adherence Response Scale-10 (MARS-10), a validated patient reported outcome measure (PRO). Data collection included patient demographics and clinical variables to assess their sarcoidosis phenotype. The patients were administered additional PROs concerning their psychosocial status, beliefs about medication use, corticosteroid side-effects and the strength of their doctor-patient relationship.

Results: 132 patients were enrolled. Their mean prednisone dose was 9.9 ± 7.5 mg/day. 75% (99/132) were adherent with corticosteroids (MARS-10 ≥ 6) and 25% (33/132) were nonadherent (MARS-10 < 6). All demographic features, education level, and annual family income were not associated with CMA. Most clinical variables including spirometry, use of additional sarcoidosis drugs, number of organs involved with sarcoidosis were not associated with CMA. Almost all PROs including a better attitude toward medication use, less psychological issues, less corticosteroid side-effects, and a stronger doctor-patient relationship were associated with better CMA. A multi-logistic regression found that patient-doctor communication and the patient's intrinsic beliefs about the use of medications remained associated with CMA.

Conclusion: We found no significant relationship between demographic or socioeconomic factors and CMA. Few clinical factors were associated with CMA. In a univariate analysis, CMA was associated with physician-doctor communication, beliefs about medication use, psychological/emotional issues, and corticosteroid side-effects. Only the first two of these factors remained associated with CMA in a multi-logistic analysis. These data suggest that CMA is heavily influenced by sarcoidosis patient beliefs about medications, and less so by patient demographics.

肉样瘤病患者坚持使用皮质类固醇的相关因素
目的:我们测量了肉样瘤病患者的皮质类固醇药物依从性(CMA),并分析了人口统计学和临床因素、对药物的看法、皮质类固醇的副作用、社会心理状态以及医患关系是否与皮质类固醇的依从性有关:方法:接受皮质类固醇激素治疗的肉样瘤病患者均符合参与条件。CMA采用经过验证的患者报告结果测量法(PRO)--用药依从性反应量表-10(MARS-10)进行测量。数据收集包括患者的人口统计学特征和临床变量,以评估他们的肉样瘤病表型。此外,还对患者的社会心理状况、用药观念、皮质类固醇的副作用以及医患关系的稳固程度进行了额外的PRO测量:结果:132 名患者入选。他们的平均泼尼松剂量为 9.9 ± 7.5 毫克/天。75%的患者(99/132)坚持使用皮质类固醇(MARS-10 ≥ 6),25%的患者(33/132)不坚持使用皮质类固醇(MARS-10 结论:我们发现,人口统计学和皮质类固醇副作用之间没有显著关系:我们发现人口统计或社会经济因素与 CMA 之间没有明显关系。与 CMA 相关的临床因素很少。在单变量分析中,CMA 与医患沟通、用药观念、心理/情绪问题和皮质类固醇副作用有关。在多重逻辑分析中,只有前两个因素仍与 CMA 相关。这些数据表明,肉样瘤患者的用药观念对 CMA 的影响很大,而患者的人口统计学因素对 CMA 的影响较小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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