LACK OF AGREEMENT BETWEEN A POINT-OF-CARE BLOOD URIC ACID METER AND A BENCHTOP CHEMISTRY ANALYZER IN EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA).

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Carly Harkey, Matthew C Allender, Julie D Sheldon, Kaitlin Moorhead, Kelcie Fredrickson, Laura Adamovicz
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引用次数: 0

Abstract

Uric acid (UA) is excreted as an end product of protein metabolism in many reptiles, including some chelonians. Elevated plasma UA concentrations can occur due to many physiologic and pathologic changes, and determining plasma UA concentrations is part of a complete general health assessment in this taxon. UA concentrations are typically measured using benchtop chemistry analyzers, but point-of-care (POC) UA meters have also been developed for human use. However, these POC UA meters have not been investigated for use in any reptile species. The purpose of this study was to assess agreement between UA measurements produced by a standard benchtop chemistry analyzer and a POC UA meter in free-living eastern box turtles (Terrapene carolina carolina). UA concentrations were measured with a POC meter using fresh whole blood and frozen-thawed plasma and with a standard benchtop chemistry analyzer using frozen-thawed plasma. Poor-to-moderate agreement was present between each of the three methods as evidenced by mixed models, Passing-Bablok regression, Bland-Altman plots, and Cohen's κ. Differences between methods fell outside of clinically acceptable limits, indicating that the POC UA meter should not be used in eastern box turtles.

东部箱龟(terrapene carolina carolina)的护理点血尿酸测量仪与台式化学分析仪之间缺乏一致性。
尿酸(UA)是许多爬行动物(包括一些螯龙类)蛋白质代谢的最终产物,会被排出体外。许多生理和病理变化都可能导致血浆尿酸浓度升高,因此测定血浆尿酸浓度是对该类群进行全面健康评估的一部分。通常使用台式化学分析仪测量尿酸浓度,但也开发了供人类使用的护理点(POC)尿酸测量仪。不过,这些 POC 尿液分析仪尚未用于任何爬行动物物种。本研究的目的是评估标准台式化学分析仪和 POC 尿液分析仪对自由生活的东部箱龟(Terrapene carolina carolina)进行的尿液分析结果之间的一致性。使用新鲜全血和冷冻解冻血浆的 POC 测量仪和使用冷冻解冻血浆的标准台式化学分析仪测量了 UA 浓度。混合模型、Passing-Bablok回归、Bland-Altman图和Cohen's κ均表明,三种方法之间的一致性较差或中等。不同方法之间的差异超出了临床可接受的范围,这表明东方箱龟不应使用 POC 尿液分析仪。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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