Pharmacokinetics, Tissue Residues, and Withdrawal Times of Florfenicol in Chukar Partridges (Alectoris chukar).

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Sara Busra Yardimci, Fatih Sakin, Orhan Corum
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引用次数: 0

Abstract

The aim of this study was to determine pharmacokinetics of florfenicol and its metabolite florfenicol amine after a single (30 mg/kg) intravenous (IV) and oral administration of florfenicol in chukar partridges. It also aimed to investigate tissue residue and withdrawal time of florfenicol after multiple-dose (30 mg/kg, every 24 h for 5 days) oral administration. The research was carried out in two stages: pharmacokinetics and residue. Plasma and tissue concentrations of florfenicol and florfenicol amine were determined by HPLC. The elimination half-life of florfenicol was 5.25 h for IV and 5.44 h for oral. The volume of distribution at a steady state and total body clearance of florfenicol were 0.38 L/kg and 0.07 L/h/kg, respectively, after IV administration. The peak plasma concentration and bioavailability for oral administration were 45.26 ± 4.06 and 51.55%, respectively. After multiple-dose oral administration, the highest concentration was detected in the liver (9.21 μg/g) for florfenicol and in the kidney (0.67 μg/g) for florfeniol amine. The calculated withdrawal period of florfenicol was determined as 6, 3, 4, and 5 days for muscle, liver, kidney, and skin + fat, respectively. These data indicate that a 6-day WT after multiple-dose administration of florfenicol in chukar partridges can be considered safe for human consumption.

楚卡鹧鸪(Alectoris chukar)体内氟苯尼考的药代动力学、组织残留和撤药时间。
本研究旨在确定鹧鸪单次(30 毫克/千克)静脉注射和口服氟苯尼考后氟苯尼考及其代谢物氟苯尼考胺的药代动力学。研究还旨在调查多剂量(30 毫克/千克,每 24 小时一次,连续 5 天)口服氟苯尼考后的组织残留和停药时间。研究分两个阶段进行:药代动力学和残留。通过高效液相色谱法测定了血浆和组织中氟苯尼考和氟苯尼考胺的浓度。静脉注射氟苯尼考的消除半衰期为 5.25 小时,口服为 5.44 小时。静脉注射后,氟苯尼考的稳态分布容积和体内总清除率分别为 0.38 升/千克和 0.07 升/小时/千克。口服的峰值血浆浓度和生物利用度分别为 45.26 ± 4.06% 和 51.55%。多次口服给药后,氟苯尼考在肝脏中的浓度最高(9.21 μg/g),氟苯尼胺在肾脏中的浓度最高(0.67 μg/g)。经计算,肌肉、肝脏、肾脏和皮肤+脂肪的氟苯尼考停药期分别为 6、3、4 和 5 天。这些数据表明,在对鹧鸪多次施用氟苯尼考之后,6 天的 WT 期可以被认为对人类食用是安全的。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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